Arthritis

As with all my searches for scientific studies I enter in certain parameters for the search. On this web site I will continue to follow the policy of including the exact criteria I have used in my search. Also I do not then screen ANY of the studies found, based on this search. In other words, if someone else tried the same search terms as I have (possibly different because of a different date of search) they should get the same results. I do not go through the results to delete any which seem to contradict any position I have taken.

This Query

February 17, 1999

Results for your query:: Search all fields for: arthritis; Published in 1977 through 1999; Only select references with abstracts available; Show references published in English only; Show references pertaining to humans; In age group: all_adult; With an article type of: REVIEW

Documents: 1 to 100 of 946

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Number	Title	Comments
...1...	Epidemiology of rheumatoid arthritis.
...2...	Tenidap: a novel cytokine-modulating antirheumatic drug for the treatment of rheumatoid arthritis.
...3...	Enterococcal arthritis: case report and review [see comments]
...4...	Clinical assessment and clinical trials in rheumatoid arthritis.
...5...	Thymopentin treatment of rheumatoid arthritis.
...6...	Lymphoproliferative disorders in rheumatoid arthritis patients on low-dose methotrexate.
...7...	Sporotrichal arthritis in south central Kansas.
...8...	Arthritis and women's health: prevalence, impact, and prevention.
...9...	Group G streptococcal arthritis: case report and review of the literature.
...10...	Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases [see comments]
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...11...	Complications of humeral head replacement for proximal humeral fractures.
...12...	Radiographic evaluation of the upper cervical spine in rheumatoid arthritis: a retrospective analysis.
...13...	Is instillation drainage for the treatment of infected joints, bones and soft tissues still up to date?
...14...	Elderly-onset rheumatoid arthritis.
...15...	Sacral insufficiency fractures in the elderly.
...16...	Invasive staphylococcal infections complicating percutaneous transluminal coronary angioplasty: three cases and review [see comments]
...17...	Rapid destructive arthritis of the shoulder.
...18...	Septic arthritis of the glenohumeral joint. A report of 11 cases and review of the literature.
...19...	Osteoarticular tuberculosis.
...20...	Lyme disease: an infectious and postinfectious syndrome.
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...21...	Evidence of hepatitis C virus antibodies in the cryoprecipitate of patients with mixed cryoglobulinemia.
...22...	Clinical features and antibiotic treatment of septic arthritis and osteomyelitis due to Yersinia enterocolitica.
...23...	Quinidine-induced rheumatic syndromes.
...24...	Two new cancer locations accompanied with palmar fasciitis and polyarthritis.
...25...	Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
...26...	Severe infections caused by Propionibacterium acnes: an underestimated pathogen in late postoperative infections.
...27...	Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls.
...28...	Whipple disease. Clinical review of 52 cases. The SNFMI Research Group on Whipple Disease. Société Nationale Française de Médecine Interne.
...29...	Clinical pharmacokinetics of naproxen.
...30...	Rheumatic manifestations of Campylobacter jejuni and C. fetus infections in adults.
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...31...	Arthritis of leprosy.
...32...	Risk factors affecting radiological failure of the socket in primary Charnley low friction arthroplasty. A 10- to 20-year followup study.
...33...	Malignancy-associated multicentric reticulohistiocytosis: a clinical, histological and immunophenotypic study.
...34...	Insufficiency stress fractures.
...35...	Physical modalities in rheumatological rehabilitation.
...36...	Hematologic malignancies and the use of methotrexate in rheumatoid arthritis: a retrospective study.
...37...	Collagen vascular diseases.
...38...	Infections during low-dose methotrexate treatment in rheumatoid arthritis [see comments]
...39...	Efficacy and gastroduodenal safety of a fixed combination of diclofenac and misoprostol in the treatment of arthritis.
...40...	Pancytopenia and severe cytopenia induced by low-dose methotrexate. Eight case-reports and a review of one hundred cases from the literature (with twenty-four deaths) [see comments]
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...41...	Rheumatoid arthritis in Congo-Brazzaville. A study of thirty-six cases.
...42...	Bacterial arthritis due to beta-hemolytic streptococci of serogroups A, B, C, F, and G. Analysis of 23 cases and a review of the literature.
...43...	The classification of psoriatic arthritis: what will happen in the future?
...44...	Autoimmune disorders, physical activity, and training, with particular reference to rheumatoid arthritis.
...45...	Four new cases of collagenous colitis with joint symptoms.
...46...	Pasteurella multocida infectious arthritis with acute gout after a cat bite.
...47...	Managing problem gout.
...48...	Benign edematous polysynovitis in the elderly (RS3PE syndrome).
...49...	HLA markers in a community-based rheumatoid arthritis series.
...50...	The epidemiology of hip osteoarthritis and rheumatoid arthritis in the Orient.
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...51...	Acute sarcoid arthritis: a favourable outcome? A retrospective survey of 49 patients with review of the literature.
...52...	Prognostic criteria in rheumatoid arthritis: can we predict which patients will require specific anti-rheumatoid treatment?
...53...	Arthrodesis of the ankle secondary to replacement.
...54...	Septic arthritis with Listeria monocytogenes during low-dose methotrexate.
...55...	Dynamic exercise therapy in rheumatoid arthritis: a systematic review.
...56...	Prosthetic joint infection due to Mycobacterium tuberculosis: a case series and review of the literature.
...57...	The arthritis of coeliac disease: prevalence and pattern in 200 adult patients.
...58...	Arthritis associated with monoclonal gammapathy: clinical characteristics.
...59...	Interventions to reduce the impact of chronic disease: community-based arthritis patient education.
...60...	Oral contraceptives and rheumatoid arthritis: results from a primary care-based incident case-control study.
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...61...	Rheumatoid arthritis and bronchiectasis. A retrospective study of fourteen cases.
...62...	Medical aspects of rheumatoid arthritis. Diagnosis and treatment.
...63...	Mycobacterium haemophilum: microbiology and expanding clinical and geographic spectra of disease in humans.
...64...	Iliopsoas bursopathies. A review of twelve cases.
...65...	Mechanisms related to psychological well-being in older women with chronic illnesses: age and disease comparisons.
...66...	Arthrodesis of the first metatarsophalangeal joint to salvage failed silicone implant arthroplasty.
...67...	Study of eight cases of cancer in 426 rheumatoid arthritis patients treated with methotrexate.
...68...	Perimenopausal and postmenopausal hormone replacement therapy. Part 1. An update of the literature on benefits and risks [see comments]
...69...	Epidemiology of spinal osteoporosis.
...70...	Nonsteroidal anti-inflammatory drugs and acute renal failure in the elderly. A risk-benefit assessment.
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...71...	Long-term results of forefoot arthroplasty in patients with rheumatoid arthritis.
...72...	Mycoplasma hominis septic arthritis: two case reports and review.
...73...	Diagnostic arthroscopy in the arthritis patient.
...74...	Septic arthritis: Arthroscopic management with local antibiotic treatment.
...75...	Multifocal cellulitis and monoarticular arthritis as manifestations of Helicobacter cinaedi bacteremia.
...76...	Sulphasalazine-induced autoimmune abnormalities in patients with rheumatic disease [see comments]
...77...	Silica-associated connective tissue disease. A study of 24 cases.
...78...	Gout or 'pseudogout': how to differentiate crystal-induced arthropathies.
...79...	The dermatologist and workers' compensation. Theory and practice.
...80...	The impact of arthritis in rural populations.
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...81...	Bronchiolitis obliterans organizing pneumonia.
...82...	Pseudoporphyria due to naproxen. A cluster of 3 cases.
...83...	The variable clinical picture of arthritis induced by human parvovirus B19. Report of seven adult cases and review of the literature.
...84...	Total ankle arthroplasty. Indications, techniques, and results.
...85...	Chronic immunity-driven polyarthritis in hairy cell leukemia. Report of a case and review of the literature.
...86...	Could diet be used to reduce the risk of developing Alzheimer's disease?
...87...	A comparison of osteoarthritis and rheumatoid arthritis: diagnosis and treatment.
...88...	Alzheimer's disease risk factors as related to cerebral blood flow.
...89...	Monarthritis: differential diagnosis.
...90...	Septic arthritis.
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...91...	Psoriatic and seronegative inflammatory arthropathy associated with a traumatic onset: 4 cases and a review of the literature.
...92...	High dose intravenous immunoglobulin therapy for rheumatic diseases: clinical relevance and personal experience.
...93...	The impact of musculoskeletal disorders on the population of the United States.
...94...	Psoriatic arthritis and hypopyon-iridocyclitis. Possible mechanism of the association of psoriasis and anterior uveitis.
...95...	Hyperimmunoglobulinemia D and periodic fever syndrome. The clinical spectrum in a series of 50 patients. International Hyper-IgD Study Group.
...96...	Musculoskeletal infections in patients with human immunodeficiency virus infection.
...97...	Effects of cyclosporin on joint damage in rheumatoid arthritis. The Italian Rheumatologists Study Group on Rheumatoid Arthritis.
...98...	The economic cost and social and psychological impact of musculoskeletal conditions. National Arthritis Data Work Groups [see comments]
...99...	Human immunodeficiency virus-associated atypical mycobacterial skeletal infections [published erratum appears in Semin Arthritis Rheum 1996 Aug;26(1):504]
...100...	The coexistence of systemic sclerosis and rheumatoid arthritis in five patients. Clinical and immunogenetic features suggest a distinct entity.

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HealthGate Documents

Record 1 from database: MEDLINE
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Title: Epidemiology of rheumatoid arthritis.
Author: Silman AJ
Address: ARC Epidemiology Research Unit, University of Manchester, UK.
Source: APMIS, 1994 Oct, 102:10, 721-8
Abstract: Rheumatoid arthritis remains the most important form of arthritis seen in rheumatological practice in the developed world. It presents some tantalizing epidemiological features. It is a relatively rare disease particularly in young life. It has a marked female excess in all populations studied. There are suggestions that it might be declining in incidence, though the reasons for this are unexplained. The geographical distribution of the disease is remarkably homogeneous. There is evidence of a genetic factor as witnessed by familial aggregation particularly by increased disease occurrence in identical twins; though the large majority of such twins remain disease discordant throughout life. Whilst undoubtedly one of the most important genetic factors in explaining disease occurrence is located in HLA class II, genes encoded in this region are neither necessary nor sufficient on their own for disease development. The female excess remains unexplained but it suggests a hormonal basis for disease development. Factors supporting this hypothesis include the observed protective effect of the oral contraceptive pill, the increased risk in women who are nulliparous and the increased susceptibility to disease during the first three months postpartum. This latter finding may be linked with breast feeding: women who have breast fed, particularly after their first pregnancy, have an increased risk for disease development. It is possible that this is explained by a massive increase in circulating prolactin levels.
Language of Publication: English
Unique Identifier: 95127187

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MeSH Heading (Major): Arthritis, Rheumatoid|*EP/GE/PP
MeSH Heading: Adolescence; Adult; Age Factors; Aged; Aged, 80 and over; Biological Markers; Female; Human; HLA-DR Antigens|GE; Incidence; Male; Middle Age; Pregnancy; Prevalence; Sex Factors

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, MULTICASE
ISSN: 0903-4641
Country of Publication: DENMARK

Record 2 from database: MEDLINE
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Title: Tenidap: a novel cytokine-modulating antirheumatic drug for the treatment of rheumatoid arthritis.
Author: Breedveld F
Address: Department of Rheumatology, University Hospital, Leiden, The Netherlands.
Source: Scand J Rheumatol Suppl, 1994, 100:, 31-44
Abstract: Tenidap is a novel, once-daily, cytokine modulating antirheumatic drug indicated for the treatment of rheumatoid arthritis (RA). In vitro, tenidap significantly inhibits the production of the pro-inflammatory cytokines, interleukin-1, interleukin-6 and tumour necrosis factor in human cell lines, and inhibits cytokine-mediated processes such as cartilage degradation, bone resorption, metalloprotease synthesis, endothelial cell adhesion and monocyte differentiation. Tenidap also inhibits cyclo-oxygenase. In RA patients, tenidap 120 mg/day is clinically equivalent to the combination of disease-modifying antirheumatic agents plus non-steroidal anti-inflammatory drugs (NSAIDs) and significantly more effective than NSAIDs. Tenidap also produces rapid, profound and sustained reductions in the serum levels of the acute phase proteins, C-reactive protein and serum amyloid A, an effect suggestive of disease modifying properties. In addition, tenidap reduces circulating levels of IL-6 in RA patients. Tenidap is well tolerated.
Language of Publication: English
Unique Identifier: 95167424

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MeSH Heading (Major): Anti-Inflammatory Agents, Non-Steroidal|AE/*TU; Arthritis, Rheumatoid|CO/*DT/ME; Cytokines|DE/*ME; Indoles|AE/*TU
MeSH Heading: Acute-Phase Proteins|ME; Adult; Aged; Aged, 80 and over; Animal; Clinical Trials, Phase III; Consumer Product Safety; Disease Models, Animal; Female; Human; Male; Middle Age; Rats; Treatment Outcome

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0301-3847
Country of Publication: NORWAY

Record 3 from database: MEDLINE
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Title: Enterococcal arthritis: case report and review [see comments]
Author: Raymond NJ; Henry J; Workowski KA
Address: Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Source: Clin Infect Dis, 1995 Sep, 21:3, 516-22
Abstract: We report a case of septic arthritis due to Enterococcus species and review 18 additional cases reported in the literature from 1966 through 1993 for which clinical or treatment data were available. In 11 of the 19 cases, prosthetic joints were affected (9 knees, 2 hips) and in 8 cases, native joints were affected. Of those patients with prosthetic joint infections, 6 had preexisting osteoarthritis and 3 had rheumatoid arthritis; only one patient with native joint infection had a recognized (although unspecified), preexisting joint abnormality. Pain, fever (temperature, > 37 degrees C), and tenderness were the most common clinical findings in patients with native joint infections. The microbiological diagnosis was made by culture of synovial fluid or synovial tissue (16 of 19), blood (1 of 19), or an unstated specimen (2 of 19). Polymicrobial infection was present in 6 (32%) of 19 patients. Of fourteen patients treated with either a parenteral penicillin (11 of 19) or a glycopeptide (3 of 19), 11 made an uncomplicated recovery. An aminoglycoside was also used to treat 7 of these 14 patients (4 of these 7 had prosthetic joints). All 11 prosthetic joint infections were ultimately clinically cured; for most of these patients, the original prosthesis was removed. For two patients with native joint infections, amputation of the infected limb was necessary to cure the infection.
Language of Publication: English
Unique Identifier: 96077366

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MeSH Heading (Major): Arthritis, Infectious|DI/*ET/TH; Enterococcus faecalis|*/PY; Gram-Positive Bacterial Infections|DI/*ET/TH
MeSH Heading: Adult; Aged; Aged, 80 and over; Case Report; Enterococcus|PY; Female; Human; Infant; Joint Prosthesis; Male; Middle Age

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 1058-4838
Country of Publication: UNITED STATES

Record 4 from database: MEDLINE
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Title: Clinical assessment and clinical trials in rheumatoid arthritis.
Author: van Riel PL; van de Putte LB
Address: Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
Source: Curr Opin Rheumatol, 1994 Mar, 6:2, 132-9
Abstract: Important progress has been reported over the past year on evaluation and standardization of disease activity variables in rheumatoid arthritis and their relation to outcome measures. Core sets of variables have been established both in the United States and Europe, showing a high degree of resemblance. A recently proposed classification of antirheumatic drugs seeks to make a clear distinction between drugs that modify symptoms and those that actually control the disease. This classification may have a definite impact on design and methodology of future clinical trials.
Language of Publication: English
Unique Identifier: 94296852

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MeSH Heading (Major): Arthritis, Rheumatoid|*PP/TH
MeSH Heading: Adult; Aged; Aged, 80 and over; Clinical Trials; Human; Middle Age; Outcome Assessment (Health Care)

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 1040-8711
Country of Publication: UNITED STATES

Record 5 from database: MEDLINE
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Title: Thymopentin treatment of rheumatoid arthritis.
Author: Sundal E; Bertelletti D
Address: Cilag spa, Cologno Monzese, Italy.
Source: Arzneimittelforschung, 1994 Oct, 44:10, 1145-9
Abstract: Although the etiology of rheumatoid arthritis (RA) is unknown, there is solid evidence that immunological factors play a pivotal role in its pathogenesis. It seems that a hyporeactivity of local (intraarticular) T-suppressor cells would permit an excessive immune response that ultimately leads to the classical symptoms and signs of inflammation and cartilage damage. Thymopentin is a synthetic pentapeptide (Arg-Lys-Asp-Val-Tyr) which represents the active biologic site (sequence 32-36) of the native thymic hormone thymopoietin, containing 49 amino acids. Thymopoietin and thymopentin have been shown to possess immuno-normalizing properties in a number of animal model systems. Low concentrations of the hormone characteristically stimulate the OKT4-positive cells, whereas higher concentrations additionally induce stimulation of OKT8-positive cells. This report summarizes the clinical experience collected by Italian investigators, and discusses the results with a view to previously published papers.
Language of Publication: English
Unique Identifier: 95118416

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MeSH Heading (Major): Arthritis, Rheumatoid|*DT; Thymopentin|*TU
MeSH Heading: Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Female; Human; Italy; Male; Middle Age; Molecular Sequence Data

Publication Type: CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; REVIEW; REVIEW, TUTORIAL
ISSN: 0004-4172
Country of Publication: GERMANY

Record 6 from database: MEDLINE
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Title: Lymphoproliferative disorders in rheumatoid arthritis patients on low-dose methotrexate.
Author: Sibilia J; Lioté F; Mariette X
Address: Rheumatology Department, Hautepierre Teaching Hospital, Strasbourg, France.
Source: Rev Rhum Engl Ed, 1998 Apr, 65:4, 267-73
Abstract: Methotrexate is the most widely used second-line treatment in rheumatoid arthritis because of its excellent efficacy and safety profile. However, since 1991, about 100 cases of lymphoproliferative disorders have been reported in rheumatoid arthritis patients under methotrexate therapy. Four characteristics similar to those in lymphomas associated with immunodeficiency were identified during a review of the 48 cases for which detailed information is available. (1) Most cases were non-Hodgkin's B-cell lymphomas of the large cell or diffuse mixed type. (2) Extranodal involvement (55% of cases) was unusually common. (3) Evidence of Epstein-Barr infection was found in 46% of tested patients. (4) Of the 14 patients treated by methotrexate withdrawal alone, eight achieved a full remission, with follow-ups ranging from one to five years. These characteristics suggest a role for two factors: (1) the abnormalities in cell-mediated immunity seen in rheumatoid arthritis may promote latent Epstein-Barr virus infection, which may in turn lead to proliferation of malignant lymphoid cells; (2) the immunomodulatory effects of methotrexate may promote the development not only of opportunistic infections but also of Epstein-Barr virus-related lymphoproliferative disorders. There is no firm evidence to date that methotrexate has a direct oncogenic effect and no excess in malignant diseases has been reported with this drug. In conclusion, the rate of occurrence of lymphoproliferative disorders induced by low-dose methotrexate therapy remains controversial, although the characteristics of the malignancies and the possibility of a complete remission after methotrexate withdrawal militate against a chance association. Epidemiologic and other studies are needed to clarify this issue.
Language of Publication: English
Unique Identifier: 98262529

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MeSH Heading (Major): Antirheumatic Agents|*TU; Arthritis, Rheumatoid|*CO/*DT; Immunocompromised Host|*; Lymphoma|CI/*CO/VI; Methotrexate|*TU
MeSH Heading: Adolescence; Adult; Aged; Aged, 80 and over; Herpesviridae Infections|CO; Herpesvirus 4, Human|IP; Human; Middle Age; Tumor Virus Infections|CO

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 1169-8446
Country of Publication: FRANCE

Record 7 from database: MEDLINE
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Title: Sporotrichal arthritis in south central Kansas.
Author: Howell SJ; Toohey JS
Address: Department of Surgery, University of Kansas School of Medicine-Wichita, USA.
Source: Clin Orthop, 1998 Jan, :346, 207-14
Abstract: Sporotrichal arthritis is a rare disease, with only 51 cases reported in the English literature. Thirteen patients with sporotrichal arthritis have been treated at Wichita area hospitals since 1979. Most of the patients were middle aged men. Significant alcohol intake was noted in 77% of the patients. There were 17 joints involved in the cases, including 10 knees, three interphalangeal joints, one elbow, one midtarsal, one intercarpal, and one metatarsophalangeal joint. The typical appearance was an afebrile patient with a mildly swollen warm joint without erythema. The leukocyte counts were normal in 85% of patients, and the erythrocyte sedimentation rates were elevated in 100%. The patients had various treatments and responses. Response rates included intravenous amphotericin B (16%), ketoconazole (40%), and arthrodesis (100%). Sporotrichal arthritis may be more common than previously thought. It should be considered early in the differential diagnosis of monoarthritis.
Language of Publication: English
Unique Identifier: 98238290

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MeSH Heading (Major): Arthritis|*MI/RA/TH; Sporotrichosis|DT/*PA
MeSH Heading: Adult; Aged; Aged, 80 and over; Antifungal Agents|TU; Arthrodesis; Diagnosis, Differential; Female; Human; Kansas; Male; Middle Age; Retrospective Studies

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW LITERATURE
ISSN: 0009-921X
Country of Publication: UNITED STATES

Record 8 from database: MEDLINE
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Title: Arthritis and women's health: prevalence, impact, and prevention.
Author: Callahan LF; Rao J; Boutaugh M
Address: Aging Studies Branch, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. leigh.thurston@mhs.unc.edu
Source: Am J Prev Med, 1996 Sep, 12:5, 401-9
Abstract: INTRODUCTION: Our objectives were to review the prevalence and impact of arthritis in women and to present information regarding strategies for prevention of arthritis in women. DISCUSSION: Arthritis is one of the most prevalent chronic conditions in the United States and the most prevalent chronic condition in women. In addition, arthritis is one of the leading causes of disability and limitations in activities of daily living, and its economic, psychological, and social impact is enormous. Some of the effects of arthritis, such as medical care costs and lost wages, are easily translated into economic terms, but others, such as the inability to play sports, a reduction in housekeeping activities, or pain, are not. CONCLUSIONS: Although arthritis is the most frequent and disabling chronic condition among women, its public health importance has not been previously emphasized. Public health agencies and health care providers should consider the following strategies to reduce the impact of arthritis among women: (1) promote primary prevention of arthritis through weight reduction and the reduction of sports- or occupational-related joint injury and (2) encourage the early detection and appropriate management of arthritis in women through use of medical and physical therapy, exercise, and established educational programs.
Language of Publication: English
Unique Identifier: 97066171

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MeSH Heading (Major): Arthritis|EC/*EP/PC; Women's Health|*
MeSH Heading: Activities of Daily Living; Adaptation, Psychological; Adolescence; Adult; Aged; Aged, 80 and over; Cost of Illness; Female; Human; Mental Health; Middle Age; Prevalence; Quality of Life; Support, Non-U.S. Gov't; United States|EP

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0749-3797
Country of Publication: UNITED STATES

Record 9 from database: MEDLINE
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Title: Group G streptococcal arthritis: case report and review of the literature.
Author: Bronze MS; Whitby S; Schaberg DR
Address: Department of Medicine, University of Tennessee, Memphis, USA.
Source: Am J Med Sci, 1997 Apr, 313:4, 239-43
Abstract: Nongonococcal septic arthritis in adults is usually caused by infections with staphylococcal or streptococcal species. In patients with underlying diseases, especially those with chronic joint disease or malignancy, bacterial isolates from infected joint spaces may include group G streptococci. Occasionally, group G streptococcal arthritis may occur in otherwise healthy individuals. We report a case of pyogenic sacroiliitis in a healthy young adult and review the pertinent literature concerning group G streptococcal arthritis.
Language of Publication: English
Unique Identifier: 97253917

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MeSH Heading (Major): Arthritis, Infectious|DI/*ET; Streptococcal Infections|DI/*ET
MeSH Heading: Adolescence; Adult; Aged; Aged, 80 and over; Case Report; Child; Female; Human; Male; Middle Age; Sacroiliac Joint

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0002-9629
Country of Publication: UNITED STATES

Record 10 from database: MEDLINE
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Title: Spontaneous regression of lymphoproliferative disorders in patients treated with methotrexate for rheumatoid arthritis and other rheumatic diseases [see comments]
Author: Salloum E; Cooper DL; Howe G; Lacy J; Tallini G; Crouch J; Schultz M; Murren J
Address: Department of Medicine, Yale University School of Medicine, Yale Cancer Center, New Haven, CT 06520-8032. emile-salloum@qm.yale.edu
Source: J Clin Oncol, 1996 Jun, 14:6, 1943-9
Abstract: PURPOSE: To determine the clinicopathologic features of lymphoproliferative disorders (LPD) that occur in the setting of methotrexate (MTX) therapy for rheumatic diseases (RD) and to define the relationship between the presence of Epstein-Barr virus (EBV) in tumor cells and the response of LPD to MTX withdrawal. PATIENTS AND METHODS: In addition to nine new cases, we analyzed 28 cases previously reported in the literature of LPD in patients receiving MTX for RD. In addition to MTX, immunosuppressive therapy included corticosteroids in 19 patients, azathioprine in three, and cyclosporine in one. Extranodal disease was identified in 16 patients, but none had CNS involvement. Pathologic findings included five cases of Hodgkin's disease and seven low-grade lymphomas. The remaining patients had intermediate or aggressive lymphomas. In situ hybridization studies (ISHS) for EBV-RNA transcripts were positive in 12 of 27 patients (44%). RESULTS: Among 37 patients, 16 were initially observed after MTX withdrawal without additional antitumor therapy. Six achieved a spontaneous complete remission (CR), three had a partial response (PR), one had a minimal response, and six had no response to MTX withdrawal. Of 10 responding patients, EBV was detected by ISHS (n = 6) or polymerase chain reaction (PCR) (n = 2); one patient had a CR despite the absence of EBV by PCR and one had a CR but did not have viral assays performed. Only one of six patients with negative EBV by ISHS or PCR responded to MTX withdrawal. CONCLUSION: MTX withdrawal and observation for a short period should be considered in the initial management of patients who develop LPD while on MTX therapy. Responses were consistently observed, but not limited to patients in whom EBV was detected by ISHS or PCR. Further studies are required to confirm these findings and to evaluate the role for EBV in LPD that occur in patients receiving MTX.
Language of Publication: English
Unique Identifier: 96243754

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MeSH Heading (Major): Antirheumatic Agents|*AE/TU; Arthritis, Rheumatoid|*DT; Immunosuppressive Agents|*AE/TU; Lymphoproliferative Disorders|*CI/VI; Methotrexate|*AE/TU
MeSH Heading: Adult; Aged; Aged, 80 and over; Female; Herpesvirus 4, Human|IP; Human; Male; Middle Age; Support, U.S. Gov't, P.H.S.

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, MULTICASE
ISSN: 0732-183X
Country of Publication: UNITED STATES

Record 11 from database: MEDLINE
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Title: Complications of humeral head replacement for proximal humeral fractures.
Author: Muldoon MP; Cofield RH
Address: Department of Orthopedics, Naval Medical Center, San Diego, California, USA.
Source: Instr Course Lect, 1997, 46:, 15-24
Abstract: The indications for humeral head replacement in acute fractures and in chronic fracture problems have been studied over many decades and are reasonably well defined. Complications have probably been understudied. Many different complications occur, and their frequency and the need for reoperation is quite high. Because of the variety of complications that occur, familiarity with preventive measures and treatment options is important, not only to deal with complications arising from endoprostheses, but also to treat musculoskeletal infections, nerve injuries, fractures, instability, nonunion of tuberosities, malunion, and rotator cuff or capsule contracture or tearing. Physicians also must be able to integrate reparative/reconstructive surgery with a program of postoperative rehabilitation. The challenges are many. Treatment often provides considerable improvement for the patient, but often the extent of the improvement is somewhat less than optimal.
Language of Publication: English
Unique Identifier: 97289025

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MeSH Heading (Major): Humeral Fractures|RA/*SU; Joint Prosthesis|*/AE; Shoulder Joint|RA/*SU
MeSH Heading: Adult; Aged; Aged, 80 and over; Antibiotic Prophylaxis; Arthritis|ET; Dislocations|ET; Female; Fractures, Malunited|ET; Human; Joint Instability|ET; Male; Middle Age; Prosthesis Failure; Reoperation; Rotator Cuff|IN; Surgical Wound Infection|PC

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0065-6895
Country of Publication: UNITED STATES

Record 12 from database: MEDLINE
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Title: Radiographic evaluation of the upper cervical spine in rheumatoid arthritis: a retrospective analysis.
Author: Kuhr M; Hohmann D; Schramm M; Martus P
Address: Department of Orthopaedic Surgery, University of Erlangen, Germany.
Source: Eur Spine J, 1996, 5:2, 107-11
Abstract: We analysed retrospectively 295 lateral roentgenograms of the cervical spine in 150 patients with classic or definite rheumatoid arthritis. In addition to measuring the atlantodental interval, measurements of the different vertical parameters described by McGregor, Ranawat and Redlund-Johnell and a new measurement method with high reproducibility were described and their results compared statistically. As a control group we analysed 100 lateral roentgenograms of the cervical spine in patients with no inflammatory disease, posttraumatic lesion, tumour or osseous deformity.
Language of Publication: English
Unique Identifier: 96320700

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MeSH Heading (Major): Arthritis, Rheumatoid|*RA; Cervical Vertebrae|*RA
MeSH Heading: Adult; Aged; Aged, 80 and over; Female; Human; Male; Middle Age; Observer Variation; Reference Standards; Reproducibility of Results; Retrospective Studies

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW LITERATURE
ISSN: 0940-6719
Country of Publication: GERMANY

Record 13 from database: MEDLINE
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Title: Is instillation drainage for the treatment of infected joints, bones and soft tissues still up to date?
Author: Schmidt J; Hackenbroch MH; Kumm D; Taravati V
Address: Klinik und Poliklinik fur Orthopadie der Universitat zu Koln, Koln, Germany.
Source: Arch Orthop Trauma Surg, 1996, 115:3-4, 149-52
Abstract: For the treatment of infected joints, bones and soft tissues, either an instillation drainage therapy or the use of gentamicin-polymethyl-methacrylate (PMMA) chains (Septopal) in addition to surgical revision and systemically given antibiotics is currently in clinical use. We investigated 102 patients treated in our clinic by means of instillation drainage and compared the results with those obtained with gentamicin-PMMA chains by other authors. The overall long-term success with non-recurrence of the infection is nearly comparable (80% instillation drainage, 84% gentamicin-PMMA chains); however, with instillation drainage the duration of hospitalisation is significantly longer (mean 42.26 days vs 15.3 - 33 days). Additionally, there was a high rate of germ shifts with instillation drainage (33.3%) and a disappointing result in 20 infected endoprostheses (9 recurrences with 11 revisions). Regarding the intensive nursing care required and the necessary isolation from other patients, instillation drainage can only be recommended for the therapy of infected joints, bones and soft tissues if the results are better in comparison with gentamicin-PMMA chains. An improvement may be achieved with the closed instillation drainage system.
Language of Publication: English
Unique Identifier: 97014747

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MeSH Heading (Major): Arthritis, Infectious|*TH; Drainage|*MT; Osteomyelitis|*TH; Soft Tissue Infections|*TH
MeSH Heading: Adolescence; Adult; Aged; Aged, 80 and over; Antibiotics, Aminoglycoside|AD; Child; Child, Preschool; Comparative Study; Female; Gentamicins|AD/TU; Human; Infant; Length of Stay; Life Tables; Male; Methylmethacrylates|TU; Middle Age; Reoperation

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, MULTICASE
ISSN: 0936-8051
Country of Publication: GERMANY

Record 14 from database: MEDLINE
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Title: Elderly-onset rheumatoid arthritis.
Author: van Schaardenburg D; Breedveld FC
Address: Department of Rheumatology, University Hospital, Leiden, The Netherlands.
Source: Semin Arthritis Rheum, 1994 Jun, 23:6, 367-78
Abstract: Elderly-onset rheumatoid arthritis (EORA), defined as rheumatoid arthritis (RA) with onset at age 60 years or over, differs slightly at presentation from younger-onset RA (YORA) by a more equal gender distribution, a higher frequency of acute onset with systemic features, more frequent involvement of the shoulder, and higher disease activity. Longitudinal studies have showed more disease activity, radiographic damage, and functional decline in patients with EORA than in those with YORA. These differences were only found in seropositive patients. Seropositive EORA was reported to be associated with HLA-DR4, in contrast to seronegative EORA. Possible heterogeneity in the pathogenesis of seronegative EORA is supported by the recognition of subsets that overlap with the clinical manifestations of other syndromes such as polymyalgia rheumatica and remitting seronegative symmetrical synovitis with pitting edema. In addition, crystal-induced arthritis and inflammatory osteoarthritis may be difficult to distinguish from EORA. The efficacy and toxicity of second-line drugs is similar in both age groups, but in the elderly caution is needed with the use of nonsteroidal antiinflammatory drugs and prednisone.
Language of Publication: English
Unique Identifier: 95025980

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MeSH Heading (Major): Arthritis, Rheumatoid|*/DI/EP/PP/TH
MeSH Heading: Aged; Aged, 80 and over; Aging; Antirheumatic Agents|TU; Diagnosis, Differential; Female; Human; Male; Middle Age; Prognosis; Sex Hormones|ME

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, ACADEMIC
ISSN: 0049-0172
Country of Publication: UNITED STATES

Record 15 from database: MEDLINE
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Title: Sacral insufficiency fractures in the elderly.
Author: Gotis Graham I; McGuigan L; Diamond T; Portek I; Quinn R; Sturgess A; Tulloch R
Address: St George Hospital, Kogarah, Australia.
Source: J Bone Joint Surg Br, 1994 Nov, 76:6, 882-6
Abstract: Sacral insufficiency fractures are not uncommon in elderly patients. We have diagnosed 20 cases in a five-year period, and have reviewed the clinical records, radiographs, CT and bone scans. We also assessed the degree of osteoporosis by measuring bone density using dual-energy X-ray absorptiometry and bone histomorphometry, and monitored the patients' functional outcome. Bone scans were positive in all 20 patients, CT showed a fracture or sclerosis in 7 of 12 patients and was useful in excluding malignancy. Plain radiographs were the least helpful, showing sclerosis in only 4 of the 20 patients. Involutional osteoporosis with a reduced bone formation rate was the most common underlying cause. Seventeen patients had complete resolution of pain within nine months, and no patient lost independence in daily activities. Increased awareness of these fractures may help to avoid unnecessary investigation and treatment. Bedrest and analgesia followed by rehabilitation provide good relief of symptoms.
Language of Publication: English
Unique Identifier: 95074217

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MeSH Heading (Major): Arthritis, Rheumatoid|*CO/PP/RA/RI; Low Back Pain|DI/*ET; Osteoporosis|*CO/PP/RA/RI; Sacrum|*IN/RA/RI; Scoliosis|*CO/PP/RA/RI; Spinal Fractures|*ET/PP/RA/RI
MeSH Heading: Aged; Aged, 80 and over; Bone Density; Densitometry, X-Ray; Female; Follow-Up Studies; Human; Male; Middle Age; Tomography, X-Ray Computed

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0301-620X
Country of Publication: ENGLAND

Record 16 from database: MEDLINE
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Title: Invasive staphylococcal infections complicating percutaneous transluminal coronary angioplasty: three cases and review [see comments]
Author: Cleveland KO; Gelfand MS
Address: Department of Medicine, Methodist Hospitals of Memphis, Tennessee, USA.
Source: Clin Infect Dis, 1995 Jul, 21:1, 93-6
Abstract: Infectious complications infrequently occur after percutaneous transluminal coronary angioplasty (PTCA) is performed. We recently treated three patients with invasive staphylococcal infections that developed after PTCA. Two patients had septic arthritis of the knee joint secondary to probable femoral endarteritis, and the third patient had an infected hematoma of the groin. Early reuse of the initial puncture site, prolonged retention of the femoral sheath, bleeding or hematoma at the femoral sheath insertion site and vascular complications such as pseudoaneurysm may predispose to infectious sequelae after PTCA. The clinician should be aware of these risks and the possibility that a patient may develop these potentially serious complications after PTCA.
Language of Publication: English
Unique Identifier: 96065618

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MeSH Heading (Major): Angioplasty, Transluminal, Percutaneous Coronary|*AE; Arthritis, Infectious|DT/*MI; Hematoma|DT/*MI; Knee Joint|*; Staphylococcal Infections|DT/*ET; Staphylococcus aureus|*IP
MeSH Heading: Aged; Aged, 80 and over; Antibiotics, Combined|TU; Case Report; Female; Groin; Human; Male; Microbial Sensitivity Tests; Middle Age; Synovial Fluid|MI

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 1058-4838
Country of Publication: UNITED STATES

Record 17 from database: MEDLINE
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Title: Rapid destructive arthritis of the shoulder.
Author: Nguyen VD
Address: University of Texas Health Science Center, San Antonio 78284-7800, USA.
Source: Skeletal Radiol, 1996 Feb, 25:2, 107-12
Abstract: Rapid destructive arthritis of the shoulder, although uncommon, has received much attention in the recent medical literature. It has been described by several authors under varied names: hemorrhagic shoulder of the elderly, Milwaukee shoulder syndrome, rapid destructive arthritis of the shoulder, apatite-associated destructive arthritis and idiopathic destructive arthritis of the shoulder. This particular form of arthritis affects mainly elderly patients, predominantly women, with limited pain, rotator cuff tear, joint instability, voluminous mildly inflammatory, blood-stained effusion, basic calcium phosphate crystals, and marked joint and bone destruction.
Language of Publication: English
Unique Identifier: 96237372

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MeSH Heading (Major): Arthritis|*/EP/ET/RA; Shoulder Joint|*/RA
MeSH Heading: Age Factors; Aged; Aged, 80 and over; Female; Hip Joint; Human; Knee Joint; Male; Middle Age; Rotator Cuff|RA; Sex Factors

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0364-2348
Country of Publication: GERMANY

Record 18 from database: MEDLINE
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Title: Septic arthritis of the glenohumeral joint. A report of 11 cases and review of the literature.
Author: Lossos IS; Yossepowitch O; Kandel L; Yardeni D; Arber N
Address: Department of Medicine, Hadassah University Hospital, Jerusalem, Israel. ilos@md2.huji.ac.il
Source: Medicine (Baltimore), 1998 May, 77:3, 177-87
Abstract: Eleven cases (6 adults and 5 pediatrics) of shoulder septic arthritis are described, and the English literature from 1960 to 1997 reviewed, for a total of 168 cases. Shoulder septic arthritis is an uncommon and difficult diagnosis requiring a high index of suspicion and early evaluation of the affected shoulder by the clinician. The disease usually involves very young infants or elderly patients (65-75 years old). Associated medical conditions were identified in 60% of the patients and include systemic disorders such as liver diseases, alcoholism, and malignancies in 46%; preceding chronic arthritic disorders in 24%; and associated infectious focus in 13% of the patients. Associated infections were more prevalent in the pediatric population. Intravenous drug abuse appears not to constitute a major risk factor; it was identified in less than 5% of patients. All patients presented with acute shoulder ache or with exacerbation of existing chronic pain in joints previously damaged. Elevated body temperature (over 38 degrees C) appeared in 67% of the adult patients and in over 90% of the pediatric patients. Shoulder arthritis was frequently accompanied by an accelerated erythrocyte sedimentation rate that may rise above 100 mm/hr. Increased white blood cell count was found in approximately 40% of patients. The initial X-rays were frequently normal, while ultrasonography supported the diagnosis in some cases by demonstrating accumulation of fluid inside the joint space. Aspiration of synovial fluid from the affected glenohumeral joint was necessary to evaluate the offending pathogen. False-negative Gram stain appeared in approximately 90% of the patients, whereas synovial fluid cultures demonstrated the pathogen in 88% of patients. Blood cultures were positive in 50% of adult patients and 90% of pediatric patients. The most common isolated pathogen was Staphylococcus aureus, which accounted for 41% of infections. Gram-negative bacilli, which accounted for about 20% of infections, are more prevalent in the pediatric population, especially the neonates. Pyogenic shoulder arthritis should first be treated with intravenous antibiotics, effective at least against staphylococcal infections, until the organisms and sensitivities are identified. Duration of antibiotic therapy should be 3-6 weeks. Unfortunately, our experience in addition to the literature summary does not allow statistical analysis and firm conclusions concerning the best therapeutic approach. However, it appears that in the adult population an operative draining procedure is preferred, whereas in the pediatric population, a closed needle aspiration, if needed at all, is the optimal treatment. With prompt antibiotic therapy and drainage of the shoulder, the patient can be expected to improve clinically, with no serious long-term debilitating effects from the disease.
Language of Publication: English
Unique Identifier: 98317311

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MeSH Heading (Major): Arthritis, Infectious|*DI/*MI/TH; Gram-Negative Bacteria|*IP; Shoulder Joint|*MI/SU
MeSH Heading: Aged; Aged, 80 and over; Antibiotics|TU; Case Report; Drainage|MT; Female; Human; Humerus; Male; Middle Age; Retrospective Studies; Synovial Fluid|MI

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0025-7974
Country of Publication: UNITED STATES
CAS Registry/EC Number: 0 (Antibiotics)

Record 19 from database: MEDLINE
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Title: Osteoarticular tuberculosis.
Author: Kosinski MA; Smith LC
Address: New York College of Podiatric Medicine, New York, USA.
Source: Clin Podiatr Med Surg, 1996 Oct, 13:4, 725-39
Abstract: Over the past several years there has been a dramatic rise in the incidence of tuberculosis. Peripheral skeletal tuberculosis is, more often than not, misdiagnosed as osteoarthritis or pyogenic osteomyelitis. Tuberculosis is no longer a "zebra" among differential diagnoses. This article reviews the pathogenesis, along with practical tips for the diagnosis and treatment of osteoarticular tuberculosis.
Language of Publication: English
Unique Identifier: 97058011

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MeSH Heading (Major): Tuberculosis, Osteoarticular|*/CO/DI/EP/MI/TH/TM
MeSH Heading: Aged; Aged, 80 and over; Arthritis, Infectious|DI/MI/PA; BCG Vaccine|AE; Diagnosis, Differential; Human; Middle Age; Osteomyelitis|MI/PA; Tuberculosis, Spinal|DI/PA

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0891-8422
Country of Publication: UNITED STATES

Record 20 from database: MEDLINE
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Title: Lyme disease: an infectious and postinfectious syndrome.
Author: Asch ES; Bujak DI; Weiss M; Peterson MG; Weinstein A
Address: Department of Medicine, New York Medical College, Valhalla 10595.
Source: J Rheumatol, 1994 Mar, 21:3, 454-61
Abstract: OBJECTIVE. To determine chronic morbidity and the variables that influence recovery in patients who had been treated for Lyme disease. METHODS. Retrospective evaluation of 215 patients from Westchester County, NY, who fulfilled Centers for Disease Control case definition for Lyme disease, were anti-Borrelia antibody positive and were diagnosed and treated at least one year before our examination. RESULTS. Erythema migrans had occurred in 70% of patients, neurological involvement in 29%, objective cardiac problems in 6%, arthralgia in 78% and arthritis in 41%. Patients were seen at a mean of 3.2 years after initial treatment. A history of relapse with major organ involvement had occurred in 28% and a history of reinfection in 18%. Anti-Borrelia antibodies, initially present in all patients, were still positive in 32%. At followup, 82 (38%) patients were asymptomatic and clinically active Lyme disease was found in 19 (9%). Persistent symptoms of arthralgia, arthritis, cardiac or neurologic involvement with or without fatigue were present in 114 (53%) patients. Persistent symptoms correlated with a history of major organ involvement or relapse but not the continued presence of anti-Borrelial antibodies. Thirty-five of the 114 (31%) patients with persistent symptoms had predominantly arthralgia and fatigue. Antibiotic treatment within 4 weeks of disease onset was more likely to result in complete recovery. Children did not significantly differ from adults in disease manifestations or in the frequency of relapse, reinfection or complete recovery. CONCLUSION. Despite recognition and treatment, Lyme disease is associated with significant infectious and postinfectious sequelae.
Language of Publication: English
Unique Identifier: 94275745

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MeSH Heading (Major): Lyme Disease|CO/DI/DT/*EP/IM
MeSH Heading: Acute Disease; Adolescence; Adult; Aged; Aged, 80 and over; Antibiotics|TU; Antibodies, Bacterial|BL; Arrhythmia|EP/MI; Borrelia burgdorferi|IM; Child; Child, Preschool; Chronic Disease; Cohort Studies; Comparative Study; Female; Follow-Up Studies; Human; Life Style; Male; Middle Age; Nervous System Diseases|EP/MI; New York|EP; Recurrence; Registries; Risk Factors; Support, Non-U.S. Gov't

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, MULTICASE
ISSN: 0315-162X
Country of Publication: CANADA

Record 21 from database: MEDLINE
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Title: Evidence of hepatitis C virus antibodies in the cryoprecipitate of patients with mixed cryoglobulinemia.
Author: Muñoz Fernández S; Barbado FJ; Martín Mola E; Gijón Baños J; Martinez Zapico R; Quevedo E; Arribas JR; González Anglada I; Vázquez JJ
Address: Rheumatology Unit, Hospital La Paz, Universidad AutÆonoma de Madrid, Spain.
Source: J Rheumatol, 1994 Feb, 21:2, 229-33
Abstract: OBJECTIVE. To describe the clinical features of 8 patients with mixed cryoglobulinemia and hepatitis C virus (HCV) infection. METHODS. A clinical study of the patients was performed. Anti-HCV antibodies were determined by ELISA and confirmed by immunoblot (RIBA) in the sera and in the cryoprecipitate. RESULTS. All patients had liver dysfunction, while most had arthralgias and/or arthritis, purpura, peripheral nervous system involvement and renal disorders. Cryocrits ranged from 1 to 6%. Six patients had type III mixed cryoglobulinemia and the remaining 2 had type II. History of blood transfusion was recorded in 2 patients. Hepatitis B virus (HBV) markers were negative in all sera samples. The cryoprecipitate of 7 patients was negative for HBV markers, but anti-HCV antibodies were positive by both ELISA and RIBA. CONCLUSION. After reviewing published reports and discussing the possible role that hepatitis C virus plays in the pathogenesis of mixed cryoglobulinemia, we conclude that HCV may stimulate immune complex formation and produce cryoglobulinemia. Therefore its investigation is recommended before the diagnosis of "essential" mixed cryoglobulinemia is established.
Language of Publication: English
Unique Identifier: 94238562

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MeSH Heading (Major): Cryoglobulinemia|ET/*IM/MI; Hepatitis Antibodies|*BL; Hepatitis C-Like Viruses|*IM/PY
MeSH Heading: Adult; Aged; Aged, 80 and over; Female; Hepatitis C|CO; Human; Male; Middle Age; Support, Non-U.S. Gov't

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0315-162X
Country of Publication: CANADA

Record 22 from database: MEDLINE
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Title: Clinical features and antibiotic treatment of septic arthritis and osteomyelitis due to Yersinia enterocolitica.
Author: Crowe M; Ashford K; Ispahani P
Address: Department of Microbiology and Public Health Laboratory, Queens Medical Centre, University Hospital, Nottingham, United Kingdom.
Source: J Med Microbiol, 1996 Oct, 45:4, 302-9
Abstract: Yersinia enterocolitica bone and joint infections are rare. Over a period of 7 months four patients with deep-seated skeletal infections due to Y. enterocolitica were seen at the University Hospital, Nottingham. Sites of infection included the knee (one patient) the hip (one) and the spine (two). None of the patients had major underlying disease or risk factors for developing invasive Y. enterocolitica infection. The organisms were sensitive to the second- and third-generation cephalosporins, gentamicin and fluoroquinolones. A literature search covering the period 1970-1994 revealed 20 other cases of skeletal infections due to Y. enterocolitica; there was no uniformity in the choice of antimicrobial agent for treating these infections. Oral ciprofloxacin was used as the principal antimicrobial agent in the patients described here and therapeutic success was achieved in three of these patients. Ciprofloxacin should be considered as first line therapy for invasive infections due to Y enterocolitica.
Language of Publication: English
Unique Identifier: 97002305

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MeSH Heading (Major): Arthritis, Infectious|*DT; Osteomyelitis|*DT; Yersinia enterocolitica|*/DE; Yersinia Infections|*DT
MeSH Heading: Administration, Oral; Adolescence; Aged; Aged, 80 and over; Anti-Infective Agents, Fluoroquinolone|PD/TU; Antibiotics, Aminoglycoside|PD; Case Report; Cephalosporins|PD; Ciprofloxacin|AD/PD/TU; Female; Gentamicins|PD; Human; Male; Middle Age

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0022-2615
Country of Publication: ENGLAND

Record 23 from database: MEDLINE
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Title: Quinidine-induced rheumatic syndromes.
Author: Alloway JA; Salata MP
Address: Department of Medicine, Malcolm Grow Medical Center, Andrews Air Force Base, MD 20331, USA.
Source: Semin Arthritis Rheum, 1995 Apr, 24:5, 315-22
Abstract: Quinidine is a commonly used antiarrhythmic agent that is rarely associated with rheumatologic toxicity. However, quinidine-induced lupus, antinuclear antibody negative lupus-like syndrome, polymyalgia rheumatica-like illness, muscle weakness, and isolated creatine phosphokinase elevation have all been reported. We present one case of quinidine drug-induced lupus and another of a quinidine-induced polymyalgia rheumatica-like illness, and review the English literature for rheumatologic toxicity due to quinidine. Prompt recognition of quinidine associated rheumatologic toxicity is important because discontinuation of the medication leads to rapid resolution of clinical symptoms.
Language of Publication: English
Unique Identifier: 95327974

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MeSH Heading (Major): Lupus Erythematosus, Systemic|*CI/DI/PP; Polymyalgia Rheumatica|*CI/DI/PP; Quinidine|*AA/AE/TU
MeSH Heading: Adult; Aged; Aged, 80 and over; Antibodies, Antinuclear|AN; Atrial Fibrillation|ET; Child; Diagnosis, Differential; Female; Hematologic Tests; Human; Hydralazine|AE; Male; Middle Age; Procainamide|AE; Prognosis

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0049-0172
Country of Publication: UNITED STATES

Record 24 from database: MEDLINE
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Title: Two new cancer locations accompanied with palmar fasciitis and polyarthritis.
Author: Grados F; Houvenagel E; Cayrolle G; Bellony R; Fardellone P; Sebert JL
Address: Rheumatology Department, North Teaching Hospital, Amiens, France.
Source: Rev Rhum Engl Ed, 1998 Mar, 65:3, 212-4
Abstract: Only 35 cases of cancer with palmar fasciitis and polyarthritis have been published to date. We report two new cases, one with a transitional cell carcinoma of the renal pelvis and the other with an adenocarcinoma of the uterus. Neither of these locations has been reported in association with palmar fasciitis and polyarthritis. Palmar fasciitis with polyarthritis can occur in a wide range of cancers and warrants extensive investigations for a malignant tumor.
Language of Publication: English
Unique Identifier: 98235569

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MeSH Heading (Major): Adenocarcinoma|*CO; Arthritis|*CO; Carcinoma, Transitional Cell|*CO; Fasciitis|*CO; Hand|*; Kidney Neoplasms|*CO; Kidney Pelvis|*; Uterine Neoplasms|*CO
MeSH Heading: Aged; Aged, 80 and over; Case Report; Female; Human; Middle Age

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 1169-8446
Country of Publication: FRANCE

Record 25 from database: MEDLINE
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Title: Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome.
Author: Kimonis VE; Goldstein AM; Pastakia B; Yang ML; Kase R; DiGiovanna JJ; Bale AE; Bale SJ
Address: Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Disease, Bethesda, Maryland 20892-2757, USA.
Source: Am J Med Genet, 1997 Mar, 69:3, 299-308
Abstract: Nevoid basal cell carcinoma syndrome (NBCC; Gorlin syndrome), an autosomal dominant disorder linked to 9q22.3-q31, and caused by mutations in PTC, the human homologue of the Drosophila patched gene, comprises multiple basal cell carcinomas, keratocysts of the jaw, palmar/plantar pits, spine and rib anomalies and calcification of the falx cerebri. We reviewed the findings on 105 affected individuals examined at the NIH since 1985. The data included 48 males and 57 females ranging in age from 4 months to 87 years. Eighty percent of whites (71/90) and 38% (5/13) of African-Americans had at least one basal cell carcinoma (BCC), with the first tumor occurring at a mean age of 23 (median 20) years and 21 (median 20) years, respectively. Excluding individuals exposed to radiation therapy, the number of BCCs ranged from 1 to > 1,000 (median 8) and 1 to 3 (median 2), respectively, in the 2 groups. Jaw cysts occurred in 78/105 (74%) with the first tumor occurring in 80% by the age of 20 years. The number of total jaw cysts ranged from 1 to 28 (median 3). Palmar pits and plantar pits were seen in 87%. Ovarian fibromas were diagnosed by ultrasound in 9/52 (17%) at a mean age of 30 years. Medulloblastoma occurred in 4 patients at a mean age of 2.3 years. Three patients had cleft lip or palate. Physical findings include "coarse face" in 54%, relative macrocephaly in 50%, hypertelorism in 42%, frontal bossing in 27%, pectus deformity in 13%, and Sprengel deformity in 11%. Important radiological signs included calcification of the falx cerebri in 65%, of the tentorium cerebelli in 20%, bridged sella in 68%, bifid ribs in 26%, hemivertebrae in 15%, fusion of the vertebral bodies in 10%, and flame shaped lucencies of the phalanges, metacarpal, and carpal bones of the hands in 30%. Several traits previously considered components of the syndrome (including short fourth metacarpal, scoliosis, cervical ribs and spina bifida occulta) were not found to be significantly increased in the affected individuals. This study delineates the frequency of the clinical and radiological anomalies in NBCC in a large population of US patients and discusses guidelines for diagnosis and management.
Language of Publication: English
Unique Identifier: 97251078

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MeSH Heading (Major): Basal Cell Nevus Syndrome|*DI/EP/PA/RT
MeSH Heading: Adolescence; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Chromosomes, Human, Pair 9; Cross-Sectional Studies; Female; Human; Infant; Jaw Cysts|CO; Male; Medulloblastoma|CO/RT; Middle Age; Urogenital Abnormalities; Urogenital System|AB

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0148-7299
Country of Publication: UNITED STATES

Record 26 from database: MEDLINE
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Title: Severe infections caused by Propionibacterium acnes: an underestimated pathogen in late postoperative infections.
Author: Jakab E; Zbinden R; Gubler J; Ruef C; von Graevenitz A; Krause M
Address: Department of Medical Microbiology, University of Zurich, Switzerland.
Source: Yale J Biol Med, 1996 Nov, 69:6, 477-82
Abstract: Propionibacterium acnes belongs to the cutaneous flora of humans and is rarely considered a pathogen in human diseases. It is a frequent contaminant in blood cultures; however, in some patients it has been identified as the causative agent of life-threatening infections. Within the last years we have observed an abrupt increase in severe P. acnes infections which prompted us to study in detail the clinical and microbiological features, risk factors, and outcomes of these cases. In a retrospective review of microbiological records of 905 Propionibacterium isolates from a five-year period (1990-95), 70 were identified from 20 patients with clinical and microbiological evidence of a P. acnes infection. The clinical syndromes included endocarditis (7 patients), post-craniotomy infections (6 patients), arthritis and spondylodiscitis (4 patients), endophthalmitis (2 patients) and pansinusitis (1 patient). The predominant predisposing conditions were previous surgery preceding the infection from 2 weeks to 4 years and implantation of foreign bodies such as prosthetic heart valves, intraocular lenses and ventriculo-peritoneal shunts. Therapy consisted of intravenous antibiotics in all cases and surgical procedures to remove infected tissue in eighteen patients. The outcome was favorable in sixteen patients (80 percent) who had a complete recovery. These data confirm the pathogenic potential of P. acnes in late post-surgical infections, in particular after implantation of a foreign body, and suggest a combined therapeutic approach with intravenous antibiotics and surgical removal of the infected tissue.
Language of Publication: English
Unique Identifier: 98098685

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MeSH Heading (Major): Gram-Positive Bacterial Infections|*MI/PP/TH; Postoperative Complications|*MI; Propionibacterium acnes|*IP
MeSH Heading: Adolescence; Adult; Aged; Aged, 80 and over; Female; Human; Male; Middle Age

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0044-0086
Country of Publication: UNITED STATES

Record 27 from database: MEDLINE
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Title: Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls.
Author: Davies NM; Anderson KE
Address: Faculty of Medicine, Department of Pharmacology and Therapeutics, University of Calgary, Alberta, Canada. ndavies@acs.ucalgary.ca
Source: Clin Pharmacokinet, 1997 Sep, 33:3, 184-213
Abstract: Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class. When given orally the absorption of diclofenac is rapid and complete. Diclofenac binds extensively to plasma albumin. The area under the plasma concentration-time curve (AUC) of diclofenac is proportional to the dose for oral doses between 25 to 150 mg. Substantial concentrations of drug are attained in synovial fluid, which is the proposed site of action for NSAIDs. Concentration-effect relationships have been established for total bound, unbound and synovial fluid diclofenac concentrations. Diclofenac is eliminated following biotransformation to glucoroconjugated and sulphate metabolites which are excreted in urine, very little drug is eliminated unchanged. The excretion of conjugates may be related to renal function. Conjugate accumulation occurs in end-stage renal disease; however, no accumulation is apparent upon comparison of young and elderly individuals. Dosage adjustments for the elderly, children or for patients with various disease states (such as hepatic disease or rheumatoid arthritis) may not be required. Significant drug interactions have been demonstrated for aspirin (acetylsalicylic acid), lithium, digoxin, methotrexate, cyclosporin, cholestyramine and colestipol.
Language of Publication: English
Unique Identifier: 97460186

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MeSH Heading (Major): Anti-Inflammatory Agents, Non-Steroidal|AD/ME/*PK/TU; Diclofenac|AD/ME/*PK/TU
MeSH Heading: Administration, Oral; Adolescence; Adult; Aged; Aged, 80 and over; Area Under Curve; Chronobiology; Dosage Forms; Dose-Response Relationship, Drug; Drug Interactions; Female; Gastrointestinal Transit; Human; Intestinal Absorption|DE; Male; Middle Age; Synovial Fluid|ME; Tissue Distribution

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0312-5963
Country of Publication: NEW ZEALAND

Record 28 from database: MEDLINE
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Title: Whipple disease. Clinical review of 52 cases. The SNFMI Research Group on Whipple Disease. Société Nationale Française de Médecine Interne.
Author: Durand DV; Lecomte C; Cathébras P; Rousset H; Godeau P
Address: Service de mÆedecine interne, Centre Hospitalier Lyon Sud, Pierre-BÆenite, France.
Source: Medicine (Baltimore), 1997 May, 76:3, 170-84
Abstract: Whipple disease is a rare, multiorgan disease with prominent intestinal manifestations. We report a retrospective clinical study of 52 patients recruited in various parts of France from 1967 to 1994. Seventy-three percent of the patients were male. Clinical manifestations preceding the diagnosis were articular for 35 patients (67%), digestive for 8 patients (15%), general for 7 patients (14%), and neurologic for 2 patients (4%). At a later stage of the disease, 44 patients (85%) presented diarrhea, weight loss, and malabsorption, while 8 patients (15%) did not show any gastrointestinal symptom throughout the development of the disease. Forty-three patients (83%) presented arthralgia or arthritis, and 11 (21%) had prominent neurologic symptoms. In addition, cardiovascular symptoms were present in 9 patients (17%); mucocutaneous symptoms, in 9 patients (17%); pleuropulmonary symptoms, in 7 patients (13%); and ophthalmologic symptoms, in 5 patients (10%). All patients but 1 were given a positive diagnosis on histopathologic criteria: jejunal biopsy for 46 patients (90%), lymph node biopsy for 3 patients (6%), brain biopsy for 1 patient (2%), postmortem jejunal and cerebral biopsy for 1 patient (2%). With treatment, the disease evolved favorably in 47 patients (90%), while 5 patients (10%) had unfavorable outcomes (2 deaths from neurologic involvement, 1 patient with chronic dementia, and 2 patients with digestive symptoms insensitive to antimicrobial therapy). Of the 41 patients initially treated successfully and whose treatment has been completed, clinical evolution after discontinuation of treatment was favorable in 34 cases (83%). Clinical relapses occurred in 7 patients. No relapse was observed after treatment by trimethoprim-sulfamethoxazole, alone or following a combination of penicillin and streptomycin, or after the combination of penicillin and streptomycin, whatever the oral follow-up treatment prescribed. The evolution of patients showing a relapse was favorable in all cases after reintroduction of antibiotic therapy. These results are discussed in the light of previously published series and case reports of Whipple disease. The diagnosis of the disease remains difficult at an early phase or when digestive symptoms are absent. It is noteworthy that proximal enteroscopy is sometimes misleading, considered normal on macroscopic examination and nonspecific on pathologic grounds. A normal erythrocyte sedimentation rate represents another pitfall. Histopathology is the key for positive and differential diagnosis, and may require multiple and repeated biopsies. Findings from molecular biology confirm the central role of an uncultured Gram-positive bacillus which was named in 1992 Tropheryma whippelii. A recent report suggests that polymerase chain reaction (PCR) analysis of peripheral blood might allow the diagnosis of Whipple disease in some cases. However, immunologic or cellular parameters such as macrophagic function may play an important, although not clearly elucidated, role in the pathogeny of the disease. Trimethoprim-sulfamethoxazole should be considered the antimicrobial agent of choice in the treatment of Whipple disease, minimizing the risk of cerebral involvement and relapses.
Language of Publication: English
Unique Identifier: 97336705

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MeSH Heading (Major): Whipple's Disease|*DI/*PP/TH
MeSH Heading: Adult; Aged; Aged, 80 and over; Female; Human; Male; Middle Age; Retrospective Studies; Treatment Outcome

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0025-7974
Country of Publication: UNITED STATES

Record 29 from database: MEDLINE
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Title: Clinical pharmacokinetics of naproxen.
Author: Davies NM; Anderson KE
Address: Faculty of Medicine, Department of Pharmacology and Therapeutics, University of Calgary, Alberta, Canada. ndavies@acs.ucalgary.ca
Source: Clin Pharmacokinet, 1997 Apr, 32:4, 268-93
Abstract: Naproxen is a stereochemically pure nonsteroidal anti-inflammatory drug of the 2-arylpropionic acid class. The absorption of naproxen is rapid and complete when given orally. Naproxen binds extensively, in a concentration-dependent manner, to plasma albumin. The area under the plasma concentration-time curve (AUC) of naproxen is linearly proportional to the dose for oral doses up to a total dose of 500 mg. At doses greater than 500 mg there is an increase in the unbound fraction of drug, leading to an increased renal clearance of total naproxen while unbound renal clearance remains unchanged. Substantial concentrations of the drug are attained in synovial fluid, which is a proposed site of action for nonsteroidal anti-inflammatory drugs. Relationships between the total and unbound plasma concentration, unbound synovial fluid concentration and therapeutic effect have been established. Naproxen is eliminated following biotransformation to glucuroconjugated and sulphate metabolites which are excreted in urine, with only a small amount of the drug being eliminated unchanged. The excretion of the 6-O-desmethylnaproxen metabolite conjugate may be tied to renal function, as accumulation occurs in end-stage renal disease but does not appear to be influenced by age. Hepatic disease and rheumatoid arthritis can also significantly alter the disposition kinetics of naproxen. Although naproxen is excreted into breast milk the amount of drug transferred comprises only a small fraction of the maternal exposure. Significant drug interactions have been demonstrated for probenecid, lithium and methotrexate.
Language of Publication: English
Unique Identifier: 97268174

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MeSH Heading (Major): Anti-Inflammatory Agents, Non-Steroidal|AD/BL/*PK/UR; Naproxen|AD/BL/*PK/UR
MeSH Heading: Absorption; Adolescence; Adult; Aged; Aged, 80 and over; Aging|ME; Child; Child, Preschool; Clinical Trials; Dose-Response Relationship, Drug; Drug Interactions; Food-Drug Interactions; Human; Middle Age; Tissue Distribution

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0312-5963
Country of Publication: NEW ZEALAND

Record 30 from database: MEDLINE
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Title: Rheumatic manifestations of Campylobacter jejuni and C. fetus infections in adults.
Author: Peterson MC
Address: Department of Medicine, LDS Hospital, Salt Lake City, Utah.
Source: Scand J Rheumatol, 1994, 23:4, 167-70
Abstract: Reports of the rheumatic manifestations of Campylobacter jejuni and C. fetus infections in adults are reviewed in order to determine the most common presentations and which individuals are at risk for rheumatic disease. Relevant English-language articles were identified through a Medline search and from bibliographies of identified articles. 105 articles were reviewed in detail. 29 cases of reactive arthritis or Reiter's syndrome following Campylobacter jejuni enteritis were identified. The knee is the most commonly involved joint and an average of 3.2 joints were involved in affected persons. HL-A B27 positive patients are more frequently affected and have higher erythrocyte sedimentation rates than HL-A B27 negative patients. Eight cases of septic arthritis and 4 cases of osteomyelitis caused by C. fetus or C. jejuni were identified, and these cases generally occurred in compromised hosts or in diseased joints.
Language of Publication: English
Unique Identifier: 94377898

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MeSH Heading (Major): Arthritis, Infectious|*MI; Campylobacter fetus|*; Campylobacter jejuni|*; Campylobacter Infections|*CO; Osteomyelitis|*MI; Reiter's Disease|IM/*MI
MeSH Heading: Adult; Aged; Arthritis, Reactive|IM/MI; Female; Human; HLA-B27 Antigen|AN; Male; Middle Age

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0300-9742
Country of Publication: NORWAY

Record 31 from database: MEDLINE
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Title: Arthritis of leprosy.
Author: Gibson T; Ahsan Q; Hussein K
Address: Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Source: Br J Rheumatol, 1994 Oct, 33:10, 963-6
Abstract: An inflammatory polyarthritis has been previously described in leprosy but accounts of the clinical characteristics have varied. All patients with joint symptoms admitted to a leprosy centre over 5 months were examined by a rheumatologist. Of 48 acute admissions, 20 (42%) had a symmetrical polyarthritis affecting the wrists and fingers. This was strikingly similar to RA in appearance. The arthritis occurred exclusively in patients with reactions mainly during anti-mycobacterial treatment. The clinical features of the joint disorder were identical in Type I (associated with alterations in immune status) and Type II (erythema nodosum leprosum) reactions. Synovial tissue from one patient revealed no mycobacteria. Four of five hand X-rays suggested small erosions of the finger joints.
Language of Publication: English
Unique Identifier: 95006000

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MeSH Heading (Major): Arthritis, Infectious|*CO/ET/RA; Leprosy|CL/*CO/DT
MeSH Heading: Acute Disease; Adolescence; Adult; Aged; Antibiotics|TU; Female; Human; Male; Middle Age; Mycobacterium leprae; Support, Non-U.S. Gov't

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0263-7103
Country of Publication: ENGLAND

Record 32 from database: MEDLINE
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Title: Risk factors affecting radiological failure of the socket in primary Charnley low friction arthroplasty. A 10- to 20-year followup study.
Author: Kobayashi S; Eftekhar NS; Terayama K; Iorio R
Address: New York Orthopaedic Hospital, College of Physicians and Surgeons of Columbia University, New York.
Source: Clin Orthop, 1994 Sep, :306, 84-96
Abstract: To identify the factors affecting Hodgkinson Type 3 or 4 radiological demarcation (presence of complete demarcation or migration, respectively) of the Charnley socket, 328 sockets with 10- to 20-year followup were studied. Fifty-five sockets (16.8%) developed Type 3 or 4 demarcation. In the osteoarthrosis group (237 sockets), removal of eburnated bone at the acetabular roof, the presence of large acetabular angles before and after surgery, and high placement of the socket were related to development of Type 3 or 4 demarcation. In the rheumatoid group (32 sockets), young patient age predisposed the socket to Type 3 or 4 demarcation. Rapid polyethylene wear, correlated with young age, male gender, and thin cement mantle in Zones I and II, was another important factor related to Type 3 or 4 demarcation in both groups and in the entire series. These risk factors should be taken into account when assessing the indications for arthroplasty, when performing arthroplasty, and when educating the patient.
Language of Publication: English
Unique Identifier: 94349708

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MeSH Heading (Major): Acetabulum|RA/*SU; Hip Prosthesis|*
MeSH Heading: Adolescence; Adult; Age Factors; Aged; Arthritis, Rheumatoid|SU; Female; Follow-Up Studies; Hip Joint|RA; Human; Male; Middle Age; Osteoarthritis, Hip|SU; Prosthesis Failure; Risk Factors

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, MULTICASE
ISSN: 0009-921X
Country of Publication: UNITED STATES

Record 33 from database: MEDLINE
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Title: Malignancy-associated multicentric reticulohistiocytosis: a clinical, histological and immunophenotypic study.
Author: Snow JL; Muller SA
Address: Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
Source: Br J Dermatol, 1995 Jul, 133:1, 71-6
Abstract: The clinical, histopathological, and immunophenotypic characteristics of four cases of malignancy-associated multicentric reticulohistiocytosis (MMR) and one case each of diffuse cutaneous reticulohistiocytosis (DCR) and isolated reticulohistiocytoma (IR), are reviewed. In all four cases of MMR the cutaneous lesions and joint manifestations were judged to be concurrent with the diagnosis of malignancy. Malignancies observed included one case each of pancreatic adenocarcinoma, squamous cell carcinoma of the lung, metastatic melanoma and intraperitoneal grade 4 mucinous adenocarcinoma of uncertain origin. Histologically, all six cases demonstrated the typical changes of a diffuse histiocytic and multinucleated giant cell infiltrate with ground-glass cytoplasm, predominantly in the upper dermis. Immunohistochemical investigation revealed strong cytoplasmic staining with KP-1 (CD68) in all six cases. Prominent membrane staining was noted with leucocyte common antigen (CD45) in four cases (three MMR and one IR), and CD3 in four cases (three MMR and one IR). Weak membrane staining with Leu 22 (CD43) was noted in two MMR cases. UCHL-1 (CD45RO), L26 (CD20), S-100 and BerH2 stains were all uniformly negative. A prominent number of perilesional factor XIIIa-positive dermal dendrocytes were noted in the single case of IR, in contrast with the other five cases. We conclude that MMR, DCR and IR are histopathologically and immunohistochemically similar. The pattern of immunoreactivity observed is consistent with a monocyte-macrophage origin of the infiltrating tumour cells. We emphasize the paraneoplastic association of multicentric reticulohistiocytosis, which we have observed in four of 13 such cases (31%) evaluated at our institution.
Language of Publication: English
Unique Identifier: 95399258

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MeSH Heading (Major): Histiocytosis, Non-Langerhans-Cell|CO/IM/*PA; Paraneoplastic Syndromes|IM/*PA
MeSH Heading: Adult; Aged; Arthritis|ET/RA; Female; Follow-Up Studies; Human; Immunophenotyping; Male; Middle Age; Skin Diseases|ET/PA

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0007-0963
Country of Publication: ENGLAND

Record 34 from database: MEDLINE
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Title: Insufficiency stress fractures.
Author: Cooper KL
Address: Department of Diagnostic Radiology, Mayo Clinic, Rochester, Minnesota.
Source: Curr Probl Diagn Radiol, 1994 Mar, 23:2, 29-68
Abstract: Bones weakened by osteopenia have insufficient elastic resistance to withstand even the minimal mechanical stresses of normal daily activity. Repetitive subthreshold injury to these susceptible bones results in insufficiency-type stress fractures. The spine, pelvis, and lower extremities are commonly affected by these fractures. Insufficiency fractures create a diagnostic challenge for clinicians and radiologists alike. The radiographic evidence of the fracture is often so subtle that it escapes detection. Conversely, findings on other studies may be so striking that they suggest metastatic disease. Insufficiency fractures are often subjected to unnecessary biopsies, and they have been treated unwittingly with chemotherapy and radiation therapy. Radiologists are in a key position to prevent these errors. A thorough familiarity with the characteristic appearance and location of these fractures assures the correct diagnosis.
Language of Publication: English
Unique Identifier: 94228847

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MeSH Heading (Major): Arthritis|*CO/RA; Fractures, Stress|CL/ET/*RA; Osteogenesis Imperfecta|*CO/RA; Osteomalacia|*CO/RA; Osteoporosis|*CO/RA
MeSH Heading: Adolescence; Adult; Aged; Child; Female; Human; Male; Middle Age; Osteoporosis, Postmenopausal|CO/RA

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW LITERATURE
ISSN: 0363-0188
Country of Publication: UNITED STATES

Record 35 from database: MEDLINE
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Title: Physical modalities in rheumatological rehabilitation.
Author: Nicholas JJ
Address: Department of Physical Medicine and Rehabilitation, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612-3833.
Source: Arch Phys Med Rehabil, 1994 Sep, 75:9, 994-1001
Abstract: Physical modalities continue to be a part of the rehabilitation treatment of patients with arthritis. Databases Medline (1980-1992) and National Rehabilitation Information Center, Rehabdata (1956-1992), were searched for "arthritis" and (1) diathermy, (2) massage, (3) transcutaneous electrical nerve stimulation (TENS), (4) hydrotherapy, (5) counter-irritants, (6) topical ointments, (7) compression gloves, (8) superficial heat, and (9) acupuncture. The results suggest that scientific publication related to the treatment of arthritis with physical modalities has been recently less frequent. The literature reviewed suggested that ablative diathermy may be fruitful for wider trials for persistently inflamed joints, and TENS and capsaicin can provide pain relief in osteoarthritis if it is possible to deliver the treatment fully and persistently.
Language of Publication: English
Unique Identifier: 94368224

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MeSH Heading (Major): Arthritis|*RH; Physical Therapy|AE/IS/*MT
MeSH Heading: Acupuncture Therapy|MT; Administration, Cutaneous; Adult; Aged; Clinical Trials; Female; Gloves, Protective; Human; Irritants|TU; Male; Middle Age; Support, Non-U.S. Gov't

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0003-9993
Country of Publication: UNITED STATES

Record 36 from database: MEDLINE
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Title: Hematologic malignancies and the use of methotrexate in rheumatoid arthritis: a retrospective study.
Author: Moder KG; Tefferi A; Cohen MD; Menke DM; Luthra HS
Address: Division of Rheumatology and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Source: Am J Med, 1995 Sep, 99:3, 276-81
Abstract: PURPOSE: To evaluate the relationship between use of methotrexate in rheumatoid arthritis patients and development of hematologic malignancies. PATIENTS AND METHODS: We retrospectively analyzed all patients registered at the Mayo Clinic from 1976 through 1992 with rheumatoid arthritis (n = 16,263) cross-indexed with patients registered during the same period with a hematologic malignancy (n = 21,270). Adult patients were selected who had rheumatoid arthritis, were treated with a disease-modifying antirheumatic drug, and subsequently developed a hematologic malignancy. RESULTS: Thirty-nine patients met the selection criteria. Twelve of them had been given methotrexate. The characteristics of those who received methotrexate, including the type of hematologic malignancy, did not differ from those of patients who received other disease-modifying antirheumatic drugs. CONCLUSIONS: Hematologic malignancies are uncommon in patients with rheumatoid arthritis treated with disease-modifying antirheumatic drugs, including methotrexate. There does not appear to be a relationship between the peak or cumulative dose or the duration of methotrexate therapy and the subsequent development of hematologic malignancy. The histologic types of hematologic malignancy seen in the methotrexate-treated patients did not differ from those of patients treated with other disease-modifying antirheumatic drugs.
Language of Publication: English
Unique Identifier: 95382014

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MeSH Heading (Major): Arthritis, Rheumatoid|*DT; Lymphoma|*CI; Methotrexate|*AE/TU; Neoplasms, Second Primary|*CI
MeSH Heading: Adult; Aged; Female; Hodgkin Disease|CI; Human; Lymphoma, Non-Hodgkin|CI; Male; Middle Age; Retrospective Studies

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0002-9343
Country of Publication: UNITED STATES

Record 37 from database: MEDLINE
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Title: Collagen vascular diseases.
Author: Corley DE; Winterbauer RH
Address: Section of Chest and Infectious Diseases, Virginia Mason Medical Center, Seattle, WA, USA.
Source: Semin Respir Infect, 1995 Jun, 10:2, 78-85
Abstract: Systemic lupus erythematosus, polymyositis/dermatomyositis, connective tissue disease, and polyarteritis nodosa are the collagen vascular diseases (CVDs) most likely to mimic pneumonia. All can be associated with an acute illness characterized by fever, cough, dyspnea, pleural symptoms, and an abnormal chest roentgenogram. Recognition of the CVD-associated pulmonary process requires sophisticated serological testing and chemical pleural fluid analysis coupled with the exclusion of pulmonary infection and pulmonary embolization. This review emphasizes the clinical characteristics of these CVDs, the diagnostic tests most helpful in recognizing them, and the differential diagnosis of pleuroparenchymal disorders that occur in these patients.
Language of Publication: English
Unique Identifier: 96047399

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MeSH Heading (Major): Collagen Diseases|*DI; Lung Diseases|*DI; Vascular Diseases|*DI
MeSH Heading: Adult; Aged; Arthritis, Rheumatoid|DI; Biopsy; Bronchoalveolar Lavage; Bronchoscopy; Dermatomyositis|DI; Diagnosis, Differential; Female; Human; Lung|PA; Lupus Erythematosus, Systemic|DI; Male; Middle Age; Mixed Connective Tissue Disease|DI; Pleural Effusion|CH; Pneumonia|DI; Polymyositis|DI; Scleroderma, Systemic|DI

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0882-0546
Country of Publication: UNITED STATES

Record 38 from database: MEDLINE
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Title: Infections during low-dose methotrexate treatment in rheumatoid arthritis [see comments]
Author: Boerbooms AM; Kerstens PJ; van Loenhout JW; Mulder J; van de Putte LB
Address: Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
Source: Semin Arthritis Rheum, 1995 Jun, 24:6, 411-21
Abstract: We studied the infection rate in patients with rheumatoid arthritis (RA) treated with low-dose methotrexate (MTX) in a 6-year open prospective study and in a 12-month randomized double blind trial comparing MTX with azathioprine (AZA) that was followed by a 3-year open prospective study. The literature on infections during low dose MTX in RA was reviewed. We also did a search for therapy-related opportunistic infections in RA and in MTX-treated psoriasis and psoriatic arthropathy patients. In our studies the infection rate during MTX treatment was higher in severe RA than in moderate RA. In severe RA there were often 2 infections simultaneously. The majority of the infections occurred in the first 1.5 years of treatment. There was no difference in the infection rate of MTX and AZA in the comparative trial. In the literature the infection rate was highest in short-term double-blind studies. Opportunistic infections are increasingly reported in RA treated with MTX and rarely with AZA, cyclosporine A, and cyclophosphamide or in MTX treated psoriasis and psoriatic arthropathy. In RA it appears that the initial period of treatment with MTX is the most vulnerable phase for infections, with the exception of opportunistic infections, which are not limited to a certain treatment period. Probably there are more MTX-associated infections in severe RA than in moderate RA.
Language of Publication: English
Unique Identifier: 95397160

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MeSH Heading (Major): Arthritis, Rheumatoid|*DT; Azathioprine|AD/*AE; Methotrexate|AD/*AE; Opportunistic Infections|EP/*ET
MeSH Heading: Adult; Aged; Comparative Study; Double-Blind Method; Female; Human; Incidence; Male; Middle Age; Prospective Studies; Psoriasis|CO/DT; Support, Non-U.S. Gov't

Publication Type: CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; REVIEW; REVIEW LITERATURE
ISSN: 0049-0172
Country of Publication: UNITED STATES

Record 39 from database: MEDLINE
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Title: Efficacy and gastroduodenal safety of a fixed combination of diclofenac and misoprostol in the treatment of arthritis.
Author: McKenna F
Address: Rheumatic Diseases Unit, Trafford General Hospital, Davyhulme, Manchester.
Source: Br J Rheumatol, 1995 Apr, 34 Suppl 1:, 11-8
Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are an effective therapy for the management of arthritis, but their use is restricted by the risk of gastrointestinal complications from NSAID-induced ulceration. The elderly, in particular, are vulnerable to such damage and complications. Misoprostol is the only cytoprotective drug found to be effective in the prevention of both gastric and duodenal ulcers associated with NSAIDs. A fixed-combination of diclofenac 50 mg/misoprostol 200 micrograms has been evaluated for efficacy and safety in the treatment of arthritis. Pharmacokinetic studies of the fixed combination have found that no drug-drug interaction occurs between misoprostol and diclofenac after either single or multiple doses, and the bioavailability of misoprostol and diclofenac are comparable with that of misoprostol and diclofenac given alone. This fixed combination was found to be equivalent to other NSAIDs in the control of symptoms and other parameters of arthritis. The fixed combination was generally well tolerated, although the occurrence of abdominal pain and diarrhoea was slightly more frequent than with other NSAIDs. This contrasts with a 2- to 3-fold reduction in the rate of gastroduodenal damage with the fixed combination compared with the rate associated with other NSAIDs. These results indicate that the diclofenac 50 mg/misoprostol 200 micrograms combination should be considered in preference to other NSAIDs when treating patients at risk of ulcer complications.
Language of Publication: English
Unique Identifier: 95299764

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MeSH Heading (Major): Arthritis|*DT; Diclofenac|PK/*TU; Misoprostol|PK/*TU
MeSH Heading: Adolescence; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal|AE; Drug Combinations; Duodenal Ulcer|CI/PC; Female; Human; Male; Middle Age; Stomach Ulcer|CI/PC

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0263-7103
Country of Publication: ENGLAND

Record 40 from database: MEDLINE
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Title: Pancytopenia and severe cytopenia induced by low-dose methotrexate. Eight case-reports and a review of one hundred cases from the literature (with twenty-four deaths) [see comments]
Author: Berthelot JM; Maugars Y; Hamidou M; Chiffoleau A; Barrier J; Grolleau JY; Prost A
Address: Department of Rheumatology, Nantes Teaching Hospital, France.
Source: Rev Rhum Engl Ed, 1995 Jul, 62:7-8, 477-86
Abstract: Severe adverse effects of low-dose methotrexate (less than 20 mg per week) are believed to be rare. We report eight cases of severe tricytopenia or pancytopenia seen in two medical departments of the same hospital in patients receiving low-dose methotrexate. Three patients had been under methotrexate for less than one month. Of the six patients with joint disease, five had rheumatoid arthritis and one psoriatic arthritis. A review of the literature found 92 previously reported cases of severe tricytopenia or pancytopenia induced by low-dose methotrexate. Of the total of 100 cases, 24 were fatal and 25 occurred within one month of treatment initiation. Potential risk factors were identifiable retrospectively in at least 50% of cases but were not all predictable or present at treatment initiation. In 30% of cases, no explanation for the hematologic complication was found, and in an additional 20% missing data precluded definite conclusions. The role of the risk factors incriminated in the literature is discussed. Although infrequent, cytopenia is a severe complication of methotrexate therapy that warrants a number of precautions, including periodic creatinine clearance and serum albumin determinations. Furthermore, the weekly dosing schedule should be printed on methotrexate boxes.
Language of Publication: English
Unique Identifier: 96117821

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MeSH Heading (Major): Antirheumatic Agents|*AE; Arthritis, Rheumatoid|*DT; Methotrexate|*AE; Pancytopenia|*CI
MeSH Heading: Adult; Aged; Case Report; Fatal Outcome; Female; Human; Male; Middle Age; Retrospective Studies

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0035-2659
Country of Publication: FRANCE

Record 41 from database: MEDLINE
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Title: Rheumatoid arthritis in Congo-Brazzaville. A study of thirty-six cases.
Author: Bileckot R; Malonga AC
Address: Rheumatology Department, Brazzaville Teaching Hospital, Congo-Brazzaville.
Source: Rev Rhum Engl Ed, 1998 May, 65:5, 308-12
Abstract: OBJECTIVES: To define the epidemiology, clinical features and outcomes of rheumatoid arthritis in a hospital-based population in Congo-Brazzaville. PATIENTS AND METHODS: We retrospectively reviewed the medical records of the 36 subjects seen on an inpatient or outpatient basis at our rheumatology department who met American College of Rheumatology criteria for rheumatoid arthritis. RESULTS: There were 28 women and eight men (male to female ratio, 0.28), with a mean age of 43.5 years. The total number of patients seen at our department during the study period was 3518, yielding a prevalence of 1% for rheumatoid arthritis. Seven per cent of the patients with inflammatory joint disease had rheumatoid arthritis. Mean disease duration was 9.5 years (range, 1-25 years). The onset was gradual in every case and distal joints were affected first in 33 patients. All the patients but one had bilateral symmetric polyarthritis; affected joints included the proximal interphalangeal joints (n: 33), the metacarpophalangeal joints (n: 27), the wrists (n: 27), the metatarsophalangeal joints (n: 20), the knees (n: 26), the elbows (n: 18), the hips (n: 4), the temporomandibular joints (n: 4), and the cervical spine (n: 5). Boutonnière deformity of the fingers was the most common joint deformity (n: 15), followed by ulnar drift (n: 9). Three patients had tenosynovitis, two had tendon rupture, one had carpal tunnel syndrome and one had rheumatoid nodules. Rheumatoid factors were found in 70% of cases. Evidence of chondrolysis was seen on roentgenograms in every case. Gold and chloroquine were the two most commonly used second-line agents. Seven patients were on prednisone, in a mean daily dose of 6 mg. Mean follow-up was 15 months (range: 3-36 months). Steinbrocker's disease activity stage was IV in 14 patients and III in eight patients; Steinbrocker's functional stage was IV in five patients and III in three. CONCLUSION: The features and outcomes of rheumatoid arthritis in Congo-Brazzaville match textbook descriptions except for a lower prevalence of extraarticular manifestations. Similar findings have been reported for East Africa, South Africa, and some countries of West Africa.
Language of Publication: English
Unique Identifier: 98300578

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MeSH Heading (Major): Arthritis, Rheumatoid|DI/DT/*EP
MeSH Heading: Adult; Age of Onset; Age Distribution; Aged; Anti-Inflammatory Agents, Non-Steroidal|TU; Congo|EP; Developing Countries; Female; Follow-Up Studies; Human; Incidence; Male; Middle Age; Retrospective Studies; Risk Factors; Sex Distribution

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, MULTICASE
ISSN: 1169-8446
Country of Publication: FRANCE
CAS Registry/EC Number: 0 (Anti-Inflammatory Agents, Non-Steroidal)

Record 42 from database: MEDLINE
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Title: Bacterial arthritis due to beta-hemolytic streptococci of serogroups A, B, C, F, and G. Analysis of 23 cases and a review of the literature.
Author: Schattner A; Vosti KL
Address: Hebrew University Hadassah Medical School, Jerusalem, Israel.
Source: Medicine (Baltimore), 1998 Mar, 77:2, 122-39
Abstract: The clinical features, essential laboratory findings, management, and outcome of all 23 cases of septic arthritis caused by different serogroups of beta-hemolytic streptococcus (BHS) seen at the Stanford Medical Center, Stanford, CA, from July 1, 1985, through October 31, 1996, were reviewed and compared to those found in the literature. Group A streptococci (GAS) accounted for 9 (40%) of our cases; group B (GBS), for 7 (30%); and Group G (GGS), for 7 (30%). No cases were caused by Group C (GCS) or F (GFS) during this period. During the same period, GAS accounted for 66 (33%) of 200 cases of bacteremia due to BHS, GBS, for 98 (49%); GCS, for 12 (6%); GFS, for 4 (2%); and GGS, for 20 (10%). A review of potential risk factors revealed that, with the exception of GGS, male and female patients were almost equally distributed among each of the serogroups. Patients aged 50 years and older comprised 56%-77% of each group. Associated conditions and risk factors were present among most patients (19/23, 83%); autoimmune diseases and a chronic skin wound or trauma were notably present among patients with GAS, while diabetes mellitus and malignancy were more common among patients with GBS. Infected prosthetic implants were present in 7 patients, including 4/7 patients with GGS. All patients had positive cultures of synovial fluid, and 11/23 (49%) had positive blood cultures (GAS, 5/9; GBS, 6/7; and GGS, 0/7). The clinical presentation and hospital course of patients infected with the different serogroups varied. Patients infected with GAS had the most severe disease and those with GGS the least severe. Necrotizing fascitis, shock, DIC, and admission to the intensive care unit were found only among patients infected with GAS. Despite aggressive management with antimicrobial therapy and surgery, 4/23 patients died (3 patients with GAS; 1 with GBS). The isolates from our patients were not available for study; investigations by others of the biology of BHS suggest that the production of 1 or more of the streptococcal pyrogenic exotoxins by isolates of GAS may account for the differences in the severity of disease among our patients with septic arthritis caused by different serogroups of BHS. Although septic arthritis due to BHS is uncommon, such patients provide a valuable model to study features of the host-parasite interaction that may contribute to the observed differences in severity of disease.
Language of Publication: English
Unique Identifier: 98217449

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MeSH Heading (Major): Arthritis, Infectious|DI/EP/*MI/TH; Streptococcal Infections|DI/EP/*MI/TH; Streptococcus|*CL
MeSH Heading: Adult; Age Distribution; Aged; California|EP; Female; Human; Male; Microbial Sensitivity Tests; Middle Age; Risk Factors; Serotyping; Sex Distribution; Support, Non-U.S. Gov't; Treatment Outcome

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, MULTICASE
ISSN: 0025-7974
Country of Publication: UNITED STATES

Record 43 from database: MEDLINE
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Title: The classification of psoriatic arthritis: what will happen in the future?
Author: Scarpa R; Biondi Oriente C; Oriente P
Address: Department of Internal Medicine, University Federico II, Naples, Italy.
Source: J Am Acad Dermatol, 1997 Jan, 36:1, 78-83
Abstract: Some patients with psoriasis have articular involvement that falls within the spectrum of seronegative spondyloarthropathies. This form of arthritis has been classified by Moll and Wright into five clinical subsets. Recently this classification has been contested. We review the historical evolution of the concept of psoriatic arthritis and discuss its clinical spectrum.
Language of Publication: English
Unique Identifier: 97149457

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MeSH Heading (Major): Arthritis, Psoriatic|*CL/HI/PA
MeSH Heading: Adolescence; Adult; Aged; Arthritis, Rheumatoid|CL/PA; Child; Female; Finger Joint|PA; Forecasting; History of Medicine, 19th Cent.; History of Medicine, 20th Cent.; Human; Male; Middle Age; Spondylitis|CL/PA; Toe Joint|PA

Publication Type: HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0190-9622
Country of Publication: UNITED STATES

Record 44 from database: MEDLINE
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Title: Autoimmune disorders, physical activity, and training, with particular reference to rheumatoid arthritis.
Author: Shephard RJ; Shek PN
Address: School of Physical and Health Education, University of Toronto, ON Canada.
Source: Exerc Immunol Rev, 1997, 3:, 53-67
Abstract: Rheumatoid arthritis arises from a reaction of the immune system to normal body components, sometimes triggered by bacterial or viral infection. The synovia of affected joints are infiltrated by CD4+, CD19-, and plasma cells. The synovial fluid shows a sterile inflammation, with high neutrophil counts and increased concentrations of proinflammatory cytokines (particularly IL-1, IL-8, TNF-alpha and JFN-gamma). The plasma shows increased CD4+ counts and a pro-inflammatory shift in T cell populations with high titers of rheumatoid factors. Traditional treatment has included rest of the affected part, which can cause a reduction of physical condition. However, exercise induces changes in circulating immune function (including a decrease of CD4+ count) that would appear helpful in regulating inflammation. Further, there is evidence that patients can tolerate a program of regular moderate aerobic exercise. Moreover, empirical data suggest that such a prescription substantially enhances physical performance, without exacerbating either clinical or immunological markers of the disease process.
Language of Publication: English
Unique Identifier: 97279639

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MeSH Heading (Major): Arthritis, Rheumatoid|BL/*IM/TH; Autoimmune Diseases|BL/*IM/TH; Exercise Therapy|*; Exertion|*PH
MeSH Heading: Adult; Aged; Animal; Arthritis, Adjuvant|TH; Clinical Trials; Cytokines|PH; Exercise; Female; Human; Immunity, Cellular; Lymphocyte Count; Lymphocyte Subsets|IM; Male; Middle Age; Physical Conditioning, Animal; Support, Non-U.S. Gov't

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, ACADEMIC
ISSN: 1077-5552
Country of Publication: UNITED STATES

Record 45 from database: MEDLINE
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Title: Four new cases of collagenous colitis with joint symptoms.
Author: Soulier C; Baron D; Saraux A; Robert FX; Le Goff P
Address: Rheumatology Department, Morvan Teaching Hospital, Brest, France.
Source: Rev Rhum Engl Ed, 1996 Oct, 63:9, 593-9
Abstract: Collagenous colitis is characterized by chronic watery diarrhea and a greater than 10 micron-thick collagen deposit in the subepithelial layer of the colonic mucosa. Rheumatic and autoimmune diseases have been reported to occur in patients with collagenous colitis. In 1993, we managed four patients with collagenous colitis and joint diseases. One had rheumatoid arthritis, one had a spondylarthropathy and two had seronegative polyarthritis without joint destruction. Three patients had dryness of the eyes and/or mouth and two had Raynaud's phenomenon. These four cases and data from a literature review provide a basis for discussing possible links between collagenous colitis and a number of joint diseases. Although some anecdotal case-reports may reflect a chance association with inflammatory joint diseases, available evidence suggests that collagenous colitis may be a cause of enteropathic arthropathy. Recent data point to an abnormality in the differentiation of fibroblasts in the colonic mucosa, although the mechanism that initiates this abnormality remains unknown.
Language of Publication: English
Unique Identifier: 97093306

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MeSH Heading (Major): Colitis|*CO/*ME; Collagen|*ME; Diarrhea|*CO; Joint Diseases|*CO
MeSH Heading: Adult; Aged; Arthritis|CO; Arthritis, Rheumatoid|CO; Case Report; Female; Human; Male; Middle Age; Raynaud's Disease|CO; Spinal Diseases|CO

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0035-2659
Country of Publication: FRANCE

Record 46 from database: MEDLINE
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Title: Pasteurella multocida infectious arthritis with acute gout after a cat bite.
Author: Butt TS; Khan A; Ahmad A; Khan MA; Parke A; Hill DR
Address: Department of Medicine, University of Connecticut School of Medicine, Farmington, USA.
Source: J Rheumatol, 1997 Aug, 24:8, 1649-52
Abstract: A 74-year-old man with chronic lymphocytic leukemia, immune purpura, and gout presented with a painful, swollen ankle after a cat bite to his leg. On aspiration of the ankle, gram negative pleomorphic rods and monosodium urate crystals were seen and Pasteurella multocida was cultured. He was treated with ampicillin/sulbactam, joint aspiration, and intraarticular steroids, with resolution of infection and return of joint function. The syndromes of Pasteurella arthritis and crystal arthropathy with septic arthritis are reviewed.
Language of Publication: English
Unique Identifier: 97408648

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MeSH Heading (Major): Ankle Joint|*MI/PA; Arthritis, Gouty|*MI/PA; Arthritis, Infectious|*ET/PA; Bites and Stings|*MI; Cats|*; Pasteurella multocida|*IP; Pasteurella Infections|*ET/PA
MeSH Heading: Acute Disease; Adolescence; Adult; Aged; Animal; Case Report; Female; Human; Male; Middle Age

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0315-162X
Country of Publication: CANADA

Record 47 from database: MEDLINE
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Title: Managing problem gout.
Author: Fam AG
Address: Division of Rheumatology, Sunnybrook Health Science Centre, University of Toronto, Canada.
Source: Ann Acad Med Singapore, 1998 Jan, 27:1, 93-9
Abstract: For the management of acute gouty arthritis, non-steroidal anti-inflammatory drugs (NSAIDs) are the drugs of choice. In recent years, the use of colchicine has declined because of its frequent adverse reactions, and its reduced efficacy when administered more than 24 hours after onset of an acute attack. Intra-articular corticosteroid therapy (e.g. methylprednisolone acetate) is indicated for the treatment of acute mono or oligoarticular gouty arthritis in aged patients, and in those with co-morbid conditions contraindicating therapy with either NSAIDs or colchicine. Oral corticosteroids (e.g. prednisone), and both parenteral corticotrophin (ACTH) and corticosteroids (e.g. intramuscular triamcinolone acetonide) are valuable, relatively safe alternate treatment modalities in those with polyarticular attacks. For the treatment of hyperuricaemia and chronic gouty arthritis, allopurinol is the preferred urate-lowering drug. Its toxicity in elderly individuals, those with renal impairment, and in cyclosporine-treated transplant patients can be minimised by adjusting the initial dose according to the patient's creatinine clearance. In those experiencing cutaneous reactions to allopurinol, cautious desensitisation to the drug can be achieved using a schedule of gradually increasing doses. The therapeutic usefulness of uricosuric drugs is limited by the presence of renal impairment, occurrence of intolerable side-effects, or concomitant intake of salicylates. They are particularly indicated in patients allergic to allopurinol and in those with massive tophi requiring combined therapy with both allopurinol and a uricosuric.
Language of Publication: English
Unique Identifier: 98249913

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MeSH Heading (Major): Adrenal Cortex Hormones|*TU; Anti-Inflammatory Agents, Non-Steroidal|AE/*TU; Antirheumatic Agents|AE/*TU; Gout|DI/*DT; Gout Suppressants|AE/*TU
MeSH Heading: Acute Disease; Adult; Aged; Allopurinol|AE/TU; Arthritis, Gouty|DI/DT; Chronic Disease; Clinical Trials; Female; Human; Injections, Intra-Articular; Male; Middle Age; Singapore; Treatment Outcome

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0304-4602
Country of Publication: SINGAPORE

Record 48 from database: MEDLINE
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Title: Benign edematous polysynovitis in the elderly (RS3PE syndrome).
Author: Olivo D; DAmore M; Lacava R; Rossi MG; Gareri P; Fiorentini C; Mattace R
Address
Source: Clin Exp Rheumatol, 1994 Nov, 12:6, 669-73
Abstract: The Authors provide an update on benign edematous polysynovitis in the elderly and propose clinical and laboratory criteria for a correct diagnosis. They also propose the use of the term "polysynovitis" rather than polyarthritis, as they think it describes the histopathological findings of the disease better. Finally, they attempt to correctly distinguish RS3PE syndrome from polymyalgia rheumatica, rheumatoid arthritis and chondrocalcinosis.
Language of Publication: English
Unique Identifier: 95202869

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MeSH Heading (Major): Synovitis|*/CO/DI/ET/TH
MeSH Heading: Aged; Aged, 80 and over; Case Report; Diagnosis, Differential; Female; Human; Male; Middle Age; Synovial Fluid|CY; Synovial Membrane|PA; Treatment Outcome

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0392-856X
Country of Publication: ITALY

Record 49 from database: MEDLINE
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Title: HLA markers in a community-based rheumatoid arthritis series.
Author: Hakala M; Silvennoinen Kassinen S; Ikäheimo I; Isosomppi J; Tiilikainen A
Address: Department of Internal Medicine, University of Oulu, Finland. markku.hakala@oulu.fi
Source: Ann Med, 1997 Aug, 29:4, 291-6
Abstract: We wanted to investigate whether rheumatoid arthritis (RA) patients, defined by the American College of Rheumatology (ACR) 1987 criteria and selected from one community by the help of the official Finnish data registers, share the common HLA susceptibility genes. The HLA frequencies of 88 RA patients representing 85% of the prevalent cases of RA in the community were compared with those of 188 healthy controls. Fifty-four per cent of the index cases with RA had DR4 compared with 30% of the healthy controls (P <0.001). The 'RA susceptibility sequence' was found in 75% of the DRB1 genes in the index cases, but it did not correlate with the severity of the disease. The frequency of DR3 was not increased in RA patients but it was associated with features of severe disease, that is, with a high erythrocyte sedimentation rate (P<0.05), extra-articular disease (P<0.01) and prostheses in large joints (P<0.05). According to our results community-based RA patients satisfying the new ACR criteria show the common DR4 association. DR3 was the only HLA allele which showed some disease-modifying effect correlating with the severity of RA.
Language of Publication: English
Unique Identifier: 98041859

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MeSH Heading (Major): Arthritis, Rheumatoid|GE/*IM/PP; HLA Antigens|*GE/ME
MeSH Heading: Adult; Aged; Alleles; Female; Human; HLA-DR3 Antigen|GE/ME; Joint Prosthesis; Male; Middle Age; Support, Non-U.S. Gov't

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0785-3890
Country of Publication: ENGLAND

Record 50 from database: MEDLINE
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Title: The epidemiology of hip osteoarthritis and rheumatoid arthritis in the Orient.
Author: Lau EM; Symmons DP; Croft P
Address: Department of Community and Family Medicine, Chinese University of Hong Kong, Shatin.
Source: Clin Orthop, 1996 Feb, :323, 81-90
Abstract: The prevalence of hip osteoarthritis and rheumatoid arthritis has been found to be lower in Chinese, Japanese, and other Asian populations than in whites. The low prevalence of osteoarthritis hip in the Chinese and Japanese populations cannot be explained by the rarity of hip dysplasia, which is as prevalent in those two populations as in whites. As in other populations, rheumatoid arthritis in the Chinese is associated with the shared epitope of the third hypervariable region of the DR gene. However, the low prevalence of rheumatoid arthritis in the Chinese cannot be accounted for entirely by genetic factors.
Language of Publication: English
Unique Identifier: 96209693

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MeSH Heading (Major): Arthritis, Rheumatoid|EH/*EP/GE; Osteoarthritis, Hip|EH/*EP
MeSH Heading: Acetabulum|AB; Adolescence; Adult; Aged; Asia|EP; Caucasoid Race; Child; Child, Preschool; Comparative Study; Cross-Cultural Comparison; Female; Human; HLA-DR Antigens|GE; Life Style; Male; Middle Age; Mongoloid Race; Prevalence

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0009-921X
Country of Publication: UNITED STATES

Record 51 from database: MEDLINE
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Title: Acute sarcoid arthritis: a favourable outcome? A retrospective survey of 49 patients with review of the literature.
Author: Gran JT; B‡hmer E
Address: Department of Rheumatology, Central Hospital of Aust Agder, Arendal, Norway.
Source: Scand J Rheumatol, 1996, 25:2, 70-3
Abstract: Forty-nine patients, 30 males and 19 females with acute sarcoid arthritis admitted to three different hospitals in Norway were studied retrospectively. All patients had peripheral arthritis and hilar adenopathy, and 87.8% also presented with erythema nodosum (EN). Mean duration of arthritis was 3.7 months (0.5-12 months), but in 26% of the cases, duration of the inflammatory joint disease exceeded three months. Radiological bony erosions were not seen. Two patients had recurrence of acute sarcoid arthritis, 14 months and 10 years after the initial episode, respectively. Two other patients developed chronic myalgia and fibromyalgia. Four patients, one female and three males, developed chronic pulmonal sarcoidosis. Of these, two patients had simultaneous onset of acute sarcoid arthritis and parenchymal disease while two patients developed chronic lung disease three months after onset of acute sarcoid arthritis. We thus tentatively suggest that although acute sarcoid arthritis is usually a self-limiting joint disease, recurrences may occasionally occur and some cases develop chronic sarcoidosis of the lungs.
Language of Publication: English
Unique Identifier: 96216519

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MeSH Heading (Major): Arthritis|CO/DT/*ET; Sarcoidosis|*CO
MeSH Heading: Acute Disease; Adrenal Cortex Hormones|TU; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal|TU; Female; Human; Male; Middle Age; Multicenter Studies; Retrospective Studies; Time Factors; Treatment Outcome

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW LITERATURE
ISSN: 0300-9742
Country of Publication: NORWAY

Record 52 from database: MEDLINE
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Title: Prognostic criteria in rheumatoid arthritis: can we predict which patients will require specific anti-rheumatoid treatment?
Author: Kirwan JR; Quilty B
Address: Rheumatology Unit, Bristol University Division of Medicine, Bristol Royal Infirmary, UK.
Source: Clin Exp Rheumatol, 1997 May, 15 Suppl 17:, S15-25
Abstract: Longitudinal studies of rheumatoid arthritis (RA) have shown that joint damage often occurs early in the disease. Therefore, the early treatment of RA with "disease modifying" drugs is gaining acceptance. However, many patients presenting with inflammatory polyarthropathy will follow a benign course. Rheumatologists need to be able to target the use of potentially toxic drugs to those cases where the benefits clearly outweigh the risks. This approach requires reliable assessment of the prognosis at an early stage in the disease process. We have critically evaluated a large number of published studies which claim to provide clinically useful information regarding the prognosis of RA. CONCLUSION: The majority of studies have methodological flaws which limit their value. A small number of published studies exist which provide useful data about estimating the prognosis of RA. Currently evaluated prognostic indicators are only moderately successful and there is an urgent need for methodologically sound research in this area.
Language of Publication: English
Unique Identifier: 97411107

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MeSH Heading (Major): Antirheumatic Agents|*TU; Arthritis, Rheumatoid|*DI/DT/MO
MeSH Heading: Adult; Aged; Human; Longitudinal Studies; Middle Age; Prognosis; Rheumatoid Factor|DU; Survival Analysis

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0392-856X
Country of Publication: ITALY

Record 53 from database: MEDLINE
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Title: Arthrodesis of the ankle secondary to replacement.
Author: Carlsson AS; Montgomery F; Besjakov J
Address: Department of Orthopaedics MalmÂo University Hospital, Sweden.
Source: Foot Ankle Int, 1998 Apr, 19:4, 240-5
Abstract: One hundred total ankle arthroplasties were performed in our department between 1974 and 1994, and of these, 21 have been reoperated on with arthrodesis due to septic or nonseptic failures after 6 months to 15 years (median 40 months). Immobilization using a Hoffman external fixator was the dominating method. The total ankles were of six different designs. Sixteen of the 21 patients suffered from rheumatoid arthritis. Four of the 21 ankles did not fuse whereas 17 did: 13 at the first attempt and 4 after repeat arthrodesis. At the time of the review, two patients had died. Of the remaining 15 patients whose ankles had fused, all but one were satisfied or somewhat satisfied with the result. Twelve of these 15 ankles rated excellent or good according to the Mazur and Kofoed scoring systems. We conclude that arthrodesis can be performed successfully after a failed ankle arthroplasty.
Language of Publication: English
Unique Identifier: 98237215

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MeSH Heading (Major): Ankle Joint|*SU; Arthrodesis|*/AE/MT; Arthroplasty, Replacement|*
MeSH Heading: Adult; Aged; Arthritis, Rheumatoid|PP/SU; Female; Human; Male; Middle Age; Pregnancy; Salvage Therapy; Support, Non-U.S. Gov't; Treatment Failure

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 1071-1007
Country of Publication: UNITED STATES

Record 54 from database: MEDLINE
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Title: Septic arthritis with Listeria monocytogenes during low-dose methotrexate.
Author: Jansen TL; van Heereveld HA; Laan RF; Barrera P; van de Putte LB
Address: Department of Rheumatology, University Hospital Nijmegen, The Netherlands.
Source: J Intern Med, 1998 Jul, 244:1, 87-90
Abstract: We describe a 22-year-old female with systemic lupus erythematosus and lymphopenia, who developed septic arthritis of the right knee with Listeria monocytogenes type 1/2 A, whilst on low-dose methotrexate (MTX). So far, septic arthritis due to this microorganism has been reported in two other patients treated with low-dose MTX, one having rheumatoid arthritis and the other psoriatic arthritis. No reports exist on patients treated with other cytotoxic antirheumatic therapies.
Language of Publication: English
Unique Identifier: 98361495

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MeSH Heading (Major): Antirheumatic Agents|*AE; Arthritis, Infectious|*CI; Knee|*; Listeria Infections|*CI; Lupus Erythematosus, Systemic|CO/*DT; Methotrexate|*AE
MeSH Heading: Adult; Aged; Case Report; Female; Human; Lymphopenia|CO; Male; Middle Age

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0954-6820
Country of Publication: ENGLAND
CAS Registry/EC Number: 0 (Antirheumatic Agents); 59-05-2 (Methotrexate)

Record 55 from database: MEDLINE
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Title: Dynamic exercise therapy in rheumatoid arthritis: a systematic review.
Author: Van den Ende CH; Vliet Vlieland TP; Munneke M; Hazes JM
Address: Department of Rheumatology, Leiden University Medical Center, The Netherlands.
Source: Br J Rheumatol, 1998 Jun, 37:6, 677-87
Abstract: The aim of this systematic review was to determine the effectiveness of dynamic exercise therapy in improving joint mobility, muscle strength, aerobic capacity and daily functioning in patients with rheumatoid arthritis (RA). In addition, possible unwanted effects such as an increase in pain, disease activity and radiological progression were studied. A computer-aided search of the MEDLINE, Embase and SCISEARCH databases was performed to identify controlled trials on the effect of exercise therapy. Randomized trials were selected on the effect of dynamic exercise therapy in RA patients with an exercise programme fulfilling the following criteria: (a) intensity level such that heart rates exceeded 60% of maximal heart rate during at least 20 min; (b) exercise frequency > or = 2 a week; and (c) duration of intervention > or = 6 weeks. Two blinded reviewers independently selected eligible studies, rated the methodological quality and extracted data. Six out of 30 identified controlled trials met the inclusion criteria. Four of the six included studies fulfilled > or = 7/10 methodological criteria. Because of heterogeneity in outcome measures, data could not be pooled. The results suggest that dynamic exercise therapy is effective in increasing aerobic capacity and muscle strength. No detrimental effects on disease activity and pain were observed. The effects of dynamic exercise therapy on functional ability and radiological progression are unclear. It is concluded that dynamic exercise therapy has a positive effect on physical capacity. Research on the long-term effect of dynamic exercise therapy on radiological progression and functional ability is needed.
Language of Publication: English
Unique Identifier: 98330198

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MeSH Heading (Major): Arthritis, Rheumatoid|PP/*TH; Exercise Therapy|*
MeSH Heading: Activities of Daily Living; Adult; Aerobiosis; Aged; Clinical Trials; Female; Human; Joints|PP; Male; Middle Age; Muscle, Skeletal|PP

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0263-7103
Country of Publication: ENGLAND

Record 56 from database: MEDLINE
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Title: Prosthetic joint infection due to Mycobacterium tuberculosis: a case series and review of the literature.
Author: Berbari EF; Hanssen AD; Duffy MC; Steckelberg JM; Osmon DR
Address: Department of Infectious Disease, Mayo Clinic, Rochester, Minnesota, USA.
Source: Am J Orthop, 1998 Mar, 27:3, 219-27
Abstract: Prosthetic joint replacement is being performed more frequently for patients with prior septic arthritis due to Mycobacterium tuberculosis. Prosthetic joint infection due to Mycobacterium tuberculosis does occur, but is rare. We report the clinical characteristics and outcome of seven cases of Mycobacterium tuberculosis prosthetic joint infection seen at our institution over a 22-year period and summarize the English-language literature regarding current prophylaxis and treatment strategies. Tuberculous prosthetic joint infection most often represents reactivation of prior tuberculous septic arthritis. The diagnosis of tuberculous prosthetic joint disease is often delayed, because a history of prior Mycobacterium tuberculosis septic arthritis is not known. Treatment of tuberculous prosthetic joint infection requires a combined medical and surgical approach. Removal of the prosthesis has been the traditional surgical modality, followed by appropriate antituberculous therapy, but other surgical methods have been used successfully in selected cases. To decrease the risk of reactivation of infection after prosthesis implantation in patients with quiescent tuberculous septic arthritis who have not received prior antituberculous therapy, consideration should be given to preoperative or perioperative antituberculous prophylaxis.
Language of Publication: English
Unique Identifier: 98206008

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MeSH Heading (Major): Joint Prosthesis|*; Prosthesis-Related Infections|*MI/TH; Tuberculosis|*ET/TH
MeSH Heading: Adult; Aged; Arthritis, Infectious|CO; Female; Human; Male; Middle Age

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 1078-4519
Country of Publication: UNITED STATES

Record 57 from database: MEDLINE
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Title: The arthritis of coeliac disease: prevalence and pattern in 200 adult patients.
Author: Lubrano E; Ciacci C; Ames PR; Mazzacca G; Oriente P; Scarpa R
Address: Rheumatology Unit, Federico II University, Naples, Italy.
Source: Br J Rheumatol, 1996 Dec, 35:12, 1314-8
Abstract: Arthritis has often been alluded to as an extra-intestinal clinical manifestation of coeliac disease, but definitive data regarding its prevalence are still lacking. We therefore evaluated the overall prevalence of articular involvement in 200 consecutive adult coeliac patients attending routine gastroenterology follow-up and in 40 controls, and determined whether the prevalence and pattern of articular involvement varied according to the dietary status. An arthritis was present in 26% of patients and in 7.5% of controls, prevalences ranging from 41% in patients on a regular diet to 21.6% in patients on a gluten-free diet (P < 0.005). Arthritis was peripheral in 19 patients, axial in 15 and an overlap of both in 18 subjects. These data suggest that arthritis is much more common than previous reports have indicated, particularly in patients receiving an appropriate dietary regimen, and support the need for combined gastrointestinal and rheumatological follow-up in coeliac patients.
Language of Publication: English
Unique Identifier: 97163229

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MeSH Heading (Major): Arthritis|CO/*EP; Celiac Disease|CO/*EP
MeSH Heading: Adolescence; Adult; Aged; Female; Human; Male; Middle Age; Prevalence

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0263-7103
Country of Publication: ENGLAND

Record 58 from database: MEDLINE
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Title: Arthritis associated with monoclonal gammapathy: clinical characteristics.
Author: Jorgensen C; Guerin B; Ferrazzi V; Bologna C; Sany J
Address: Immuno-Rheumatology Department, HÈopital Gui de Chauliac, Montpellier, France.
Source: Br J Rheumatol, 1996 Mar, 35:3, 241-3
Abstract: We report nine cases of arthritis associated with a monoclonal gammapathy. Joint involvement was noted simultaneously or after the diagnosis of monoclonal gammapathy was made. The cases had oligoarthritis or polyarthritis mimicking rheumatoid arthritis. However, rheumatoid factor was absent in all patients, and distal interphalangeal joints were involved in two cases and sacroiliitis in one. The plasma cell dyscrasia was a multiple myeloma in two cases and monoclonal gammapathy of undetermined significance in the other patients. The light chain isotype was kappa in eight of our patients. A type I cryoglobulinaemia was associated in four cases; it was detected in the synovial fluid of two of them. We suggest that the occurrence of paraproteinaemia with chronic arthritis is more than a chance association. Moreover, a monoclonal gammapathy should be searched for in patients presenting with atypical seronegative arthritis.
Language of Publication: English
Unique Identifier: 96194182

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MeSH Heading (Major): Arthritis|*CO/PA; Paraproteinemias|*CO/PA
MeSH Heading: Adult; Aged; Chronic Disease; Female; Human; Male; Middle Age; Multiple Myeloma|CO/PA

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0263-7103
Country of Publication: ENGLAND

Record 59 from database: MEDLINE
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Title: Interventions to reduce the impact of chronic disease: community-based arthritis patient education.
Author: Goeppinger J; Lorig K
Address: School of Nursing, University of North Carolina at Chapel Hill, USA.
Source: Annu Rev Nurs Res, 1997, 15:, 101-22
Abstract: Systematic development and testing of the efficacy of educational interventions to improve functioning, prevent disability, and reduce the impact of chronic disease has been limited, perhaps because many chronic diseases disable, do not kill, and because they are managed largely within home, work, and community environments and not within the medical care system. Until recently, these factors contributed to a paucity of arthritis educational interventions. But since the impetus provided by the establishment of the Multipurpose Arthritis Centers Program of the NIH (1977), a number of arthritis patient education programs have been established and evaluated. This chapter summarizes findings from community-based arthritis patient education studies conducted between 1980 and 1995, critiques the methods of these studies, and provides guidance for state-of-the-art community-based intervention research aimed at reducing the individual and social impact of arthritis and other chronic diseases.
Language of Publication: English
Unique Identifier: 97408269

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MeSH Heading (Major): Arthritis|NU/*RH; Patient Education|*MT/TD; Self Care|*
MeSH Heading: Adult; Aged; Chronic Disease|NU/RH; Community Health Services; Human; Middle Age

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0739-6686
Country of Publication: UNITED STATES

Record 60 from database: MEDLINE
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Title: Oral contraceptives and rheumatoid arthritis: results from a primary care-based incident case-control study.
Author: Brennan P; Bankhead C; Silman A; Symmons D
Address: Arthritis and Rheumatism Council Epidemiology Research Unit, University of Manchester Medical School, England, UK.
Source: Semin Arthritis Rheum, 1997 Jun, 26:6, 817-23
Abstract: OBJECTIVE: The possibility that oral contraceptives offer a protective effect against the development of rheumatoid arthritis is still contentious. Of the 17 studies investigating this association, 11 have found a protective effect, and 6 have not. These differences are probably attributable to either selection or information biases in a subset of studies, although the exact reason is unknown. To overcome the methodological problems inherent in the design of previous studies, we have conducted a population-based case-control study. METHODS: Women who were incident cases of inflammatory polyarthritis, defined as swelling of at least two joint areas lasting at least 4 weeks, were recruited directly from primary care and compared with age-matched women from the same population. RESULTS: Cases and controls reported a similar level of "ever use" of oral contraceptives, adjusted odds ratio = 0.88 (95% confidence interval, 0.47, 1.64). The cases were, however, less likely to report using oral contraceptives at the time of onset, adjusted odds ratio = 0.22 (95% confidence interval, 0.06, 0.85). Similar results were observed for cases who satisfied the criteria for rheumatoid arthritis and cases who did not. CONCLUSION: These results indicate that only current oral contraceptive use protects against the development of inflammatory polyarthritis.
Language of Publication: English
Unique Identifier: 97356948

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MeSH Heading (Major): Arthritis, Rheumatoid|EP/*PC; Contraceptives, Oral|*TU
MeSH Heading: Adult; Aged; Case-Control Studies; Female; Great Britain|EP; Human; Middle Age; Primary Health Care; Questionnaires; Support, Non-U.S. Gov't

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0049-0172
Country of Publication: UNITED STATES

Record 61 from database: MEDLINE
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Title: Rheumatoid arthritis and bronchiectasis. A retrospective study of fourteen cases.
Author: Despaux J; Polio JC; Toussirot E; Dalphin JC; Wendling D
Address: Rheumatology Department, Jean Minjoz Hospital, BesanÀcon, France.
Source: Rev Rhum Engl Ed, 1996 Dec, 63:11, 801-8
Abstract: Since 1928, 288 cases of rheumatoid arthritis and bronchiectasis have been reported in the medical literature. The interactions between these two conditions and the etiopathogenic mechanisms they involve remain unclear. During a retrospective study of 100 rheumatoid arthritis patients and 80 bronchiectasis patients, we identified 14 additional patients with both conditions. There were 10 females and four males (ratio 2.5/1). Bronchiectasis was confirmed either by computed tomography of the chest or by bronchography. The respiratory manifestations antedated the joint disease in 12 patients, by a mean interval of 28.5 years. An infectious cause was identified in six cases. Neither the age at onset nor the duration of rheumatoid arthritis were influenced by the presence of bronchiectasis. Seven patients had 15 extraarticular manifestations suggesting potentially severe joint disease. The flares of joint and respiratory symptoms were concomitant in six patients. In six patients, the respiratory manifestations worsened after onset of the joint disease. Tests for rheumatoid factors were positive in 73% of cases. Panhypogammaglobulinemia was found in one case. Ten patients underwent lung function tests, which showed evidence of nonspecific obstructive disease. Overall, our findings are consistent with previous reports in the literature. In patients with predisposing immunogenetic factors, bronchiectasis may be involved in the genesis of rheumatoid arthritis.
Language of Publication: English
Unique Identifier: 97164254

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MeSH Heading (Major): Arthritis, Rheumatoid|*CO/DI; Bronchiectasis|*CO/DI/EP
MeSH Heading: Adult; Aged; Female; Human; Male; Middle Age; Prevalence; Prognosis; Respiratory Function Tests; Retrospective Studies; Tomography, X-Ray Computed

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW LITERATURE
ISSN: 0035-2659
Country of Publication: FRANCE

Record 62 from database: MEDLINE
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Title: Medical aspects of rheumatoid arthritis. Diagnosis and treatment.
Author: Massarotti EM
Address: Department of Medicine, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA.
Source: Hand Clin, 1996 Aug, 12:3, 463-75
Abstract: Rheumatoid arthritis commonly affects the hand and wrist. The differential diagnosis of inflammatory conditions affecting the hand is broad. A proper diagnostic approach necessitates a thoughtful interpretation of the presenting clinical features, laboratory tests, synovial fluid analysis, and radiographic data. Early, aggressive medical therapy with a combination of antiinflammatory and remittive agents may reduce mortality in selected patients and prevent the consequences of uncontrolled synovial proliferation. Despite proper medical therapy, joint destruction often results and surgical treatment of the joint deformities may be required for restoration of function.
Language of Publication: English
Unique Identifier: 96440402

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MeSH Heading (Major): Arthritis, Rheumatoid|CO/*DI/*TH; Hand|*
MeSH Heading: Adrenal Cortex Hormones|TU; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal|TU; Antirheumatic Agents|TU; Carpal Tunnel Syndrome|ET; Case Report; Diagnosis, Differential; Female; Human; Methotrexate|TU; Middle Age; Polymyalgia Rheumatica|DI; Synovial Fluid|CH; Wrist

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0749-0712
Country of Publication: UNITED STATES

Record 63 from database: MEDLINE
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Title: Mycobacterium haemophilum: microbiology and expanding clinical and geographic spectra of disease in humans.
Author: Saubolle MA; Kiehn TE; White MH; Rudinsky MF; Armstrong D
Address: Department of Pathology, Good Samaritan Regional Medical Center, Phoenix, Arizona 85006, USA.
Source: Clin Microbiol Rev, 1996 Oct, 9:4, 435-47
Abstract: Reports of the association of Mycobacterium haemophilum with disease in humans have greatly increased. At least 64 cases have now been reported, with symptoms ranging from focal lesions to widespread, systemic disease. The organism is now known to cause primarily cutaneous and subcutaneous infection, septic arthritis, osteomyelitis, and pneumonitis in patients who are immunologically compromised and lymphadenitis in apparently immunocompetent children. Underlying conditions in the compromised patients have included AIDS; renal, bone marrow, and cardiac transplantation; lymphoma; rheumatoid arthritis; marrow hypoplasia; and Crohn's disease. Reports have originated from diverse geographic areas worldwide. The epidemiology of M. haemophilum remains poorly defined; there appears to be a genetic diversity between strains isolated from different regions. The organism is probably present in the environment, but recovery by sampling has not been successful. M. haemophilum has several unique traits, including predilection for lower temperatures (30 to 32 degrees C) and requirement for iron supplementation (ferric ammonium citrate or hemin). These may in the past have compromised recovery in the laboratory. Therapy has not been well elucidated, and the outcome appears to be influenced by the patient's underlying immunosuppression. The organisms are most susceptible to ciprofloxacin, clarithromycin, rifabutin, and rifampin. Timely diagnosis and therapy require communication between clinician and the laboratory.
Language of Publication: English
Unique Identifier: 97049617

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MeSH Heading (Major): Mycobacterium haemophilum|DE/IM/IP/*PY; Mycobacterium Infections|DT/IM/*MI
MeSH Heading: Acquired Immunodeficiency Syndrome|CO/MI; Adult; Aged; Antibiotics|TU; Antitubercular Agents|TU; Arthritis, Rheumatoid|MI; Bacteriological Techniques; Child; Child, Preschool; Chromatography, High Pressure Liquid; Coronary Artery Bypass|AE; Crohn Disease|MI; Culture Media|ME; Female; Human; Immunocompromised Host; Infant; Lymphoma|MI; Male; Microbial Sensitivity Tests; Middle Age; Mycolic Acids|AN; Transplantation|AE

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, ACADEMIC
ISSN: 0893-8512
Country of Publication: UNITED STATES

Record 64 from database: MEDLINE
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Title: Iliopsoas bursopathies. A review of twelve cases.
Author: Ginesty E; Dromer C; Galy Fourcade D; Bénazet JF; Marc V; Zabraniecki L; Railhac JJ; Fournié B
Address: Rheumatology Department, Purpan Teaching Hospital, Toulouse, France.
Source: Rev Rhum Engl Ed, 1998 Mar, 65:3, 181-6
Abstract: Synovial cysts are far less common at the hip than at the knee and usually occur in patients whose hip cavity communicates with the iliopsoas bursa. We report 12 cases of enlargement of the iliopsoas bursa, nine men and three women, with a mean age of 48 years. The six patients with septic bursitis had severe symptoms similar to those seen in septic arthritis of the hip. Chronic pain with or without a palpable inguinal swelling was the main symptom in the six remaining patients, some of whom had compression of neighboring structures making the diagnosis more difficult. Ultrasonography is the best first-line investigation in patients with an inguinal swelling. Computed arthrotomography with examination of the synovial fluid or magnetic resonance imaging should be performed as a confirmatory diagnostic test. Our series provides evidence of the efficacy of appropriate antimicrobial therapy in septic cases and of corticosteroid injections into the bursa or hip cavity in nonseptic cases.
Language of Publication: English
Unique Identifier: 98235564

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MeSH Heading (Major): Bursitis|*PA/RA/US; Ilium|*PA/RA/US; Psoas Abscess|*PA/RA/US; Psoas Muscles|*PA/RA/US
MeSH Heading: Adult; Aged; Arthritis, Infectious|PA; Female; Hip Joint|PA/RA/US; Human; Male; Middle Age; Pelvic Bones|PA/RA/US; Synovial Cyst|PA; Tomography, X-Ray Computed

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 1169-8446
Country of Publication: FRANCE

Record 65 from database: MEDLINE
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Title: Mechanisms related to psychological well-being in older women with chronic illnesses: age and disease comparisons.
Author: Heidrich SM
Address: School of Nursing, University of Wisconsin-Milwaukee 53201, USA.
Source: Res Nurs Health, 1996 Jun, 19:3, 225-35
Abstract: The influence of type of illness (breast cancer versus osteoarthritis) and age on physical health and functioning, self-system interpretive mechanisms, and women's psychological well-being were examined. Self-system interpretive mechanisms are considered mediators of the effects of physical health on psychological well-being and include social comparisons, social integration, and illness perceptions. Young-old (aged 60-74) and old-old (75 +) women, diagnosed with osteoarthritis (N = 102) or breast cancer (N = 86), who volunteered for the study were interviewed using structured self-report scales. Young-old and old-old women did not differ in terms of health status, interpretive mechanisms, or on three of five indices of psychological well-being. On the other hand, women with arthritis, regardless of age, reported more functional health problems, more symptoms, and perceived their illness as more severe, more chronic, and less controllable than women with breast cancer. Although women with arthritis and breast cancer differed significantly in terms of physical health, they did not differ on multiple measures of psychological well-being. For both groups, women who made more positive social comparisons and who had more extensive social networks had higher levels of psychological well-being, regardless of physical health problems.
Language of Publication: English
Unique Identifier: 96222961

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MeSH Heading (Major): Breast Neoplasms|*PX; Osteoarthritis|*PX; Psychology, Comparative|*; Social Desirability|*
MeSH Heading: Aged; Aged, 80 and over; Chronic Disease; Comparative Study; Cross-Sectional Studies; Female; Health Status; Human; Life Style; Middle Age; Social Adjustment; Support, Non-U.S. Gov't

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW LITERATURE
ISSN: 0160-6891
Country of Publication: UNITED STATES

Record 66 from database: MEDLINE
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Title: Arthrodesis of the first metatarsophalangeal joint to salvage failed silicone implant arthroplasty.
Author: Hecht PJ; Gibbons MJ; Wapner KL; Cooke C; Hoisington SA
Address: Department of Orthopaedic Surgery, Allegheny University, Philadelphia, Pennsylvania 19102, USA.
Source: Foot Ankle Int, 1997 Jul, 18:7, 383-90
Abstract: Between 1987 and 1992, all patients presenting to the senior author with a symptomatic failed silicone implant arthroplasty refractory to conservative treatment were converted to a metatarsophalangeal joint arthrodesis. Internal fixation was achieved with either dual intrameduilary threaded Steinmann pins or an obliquely placed AO compression screw and a three- or four-hole one-third tubular dorsal neutralization plate. Bone grafting was used to maintain hallux length. Successful arthrodesis was achieved in all five feet in patients with rheumatoid arthritis. Subjectively, patients improved from an average of 0.69 before arthrodesis to 4.89 after arthrodesis. The average walking tolerance improved from 1.11 to 4.80, and the overall level of satisfaction improved from 0.0 to 4.79. The patient's ability to wear shoes improved from 0.87 to 3.1. Successful arthrodesis produces a foot that is more functional and durable than excisional arthroplasty. Subjectively, these patients stated that their level of pain, walking tolerance, and overall satisfaction improved significantly after the arthrodesis. Clinically, there was no evidence of transfer lesions, tenderness, or hallux subluxation. Hallux length was well maintained after surgery with bone grafting, but it was more difficult to obtain the alignment goals. The average postoperative metatarsophalangeal dorsiflexion angle was 15.6 degrees and the first metatarsophalangeal angle was 3.1 degrees. Despite this, patient satisfaction was high. Arthrodesis of the first metatarsophalangeal joint using a bone graft to salvage failed silicone implant arthroplasty produces acceptable subjective and radiographic results. Although technically demanding, it provides long-term stability to the hallux, restores weightbearing, and allows for maintenance of a propulsive gait. We recommend this procedure instead of an excisional arthroplasty to maintain high level of function and overall patient satisfaction.
Language of Publication: English
Unique Identifier: 97396632

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MeSH Heading (Major): Arthrodesis|*; Arthroplasty|*; Metatarsophalangeal Joint|*SU; Prostheses and Implants|*; Salvage Therapy|*; Silicones|*
MeSH Heading: Adult; Aged; Arthritis, Rheumatoid|SU; Female; Follow-Up Studies; Human; Male; Middle Age; Retrospective Studies; Treatment Failure

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 1071-1007
Country of Publication: UNITED STATES

Record 67 from database: MEDLINE
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Title: Study of eight cases of cancer in 426 rheumatoid arthritis patients treated with methotrexate.
Author: Bologna C; Picot MC; Jorgensen C; Viu P; Verdier R; Sany J
Address: Service d'Immuno-Rhumatologie, FÆedÆeration de Rhumatologie, CHU Lapeyronie, Montpellier, France.
Source: Ann Rheum Dis, 1997 Feb, 56:2, 97-102
Abstract: OBJECTIVE: To report cancer cases in 426 rheumatoid arthritis patients treated with methotrexate, and determine whether there was an increased incidence of cancer compared with patients never treated with methotrexate (rheumatoid controls) and to the whole regional population. METHODS: The duration of methotrexate treatment was 37.4 (SD 27.9) months. This population was compared with 420 rheumatoid arthritis controls and with a regional population of 812,344 people. Life table analysis was performed to compare the cancer incidence in the two rheumatoid populations. Adjustment for potentially confounding factors was done. The indirect standardisation methods was used to compare each rheumatoid population with the regional population. RESULTS: Eight cases of cancer (1.88%; 4.04 cases/1000 person years) were diagnosed in the methotrexate population v six (1.43%; 58.8 cases/1000 person years) in the rheumatoid controls. The life table method showed a higher incidence of cancer in the rheumatoid controls (P = 0.0001). In a multivariate analysis (Cox model), the only significant factor explaining this difference in the cancer incidence was age (P = 0.02). In the regional population there were 6418 new cases of cancer (0.79%; 2.85 cases/1000 person years). By the indirect standardisation method, the ratio of observed cases to expected cases of cancer in each of the rheumatoid populations was not significantly different from 1. CONCLUSIONS: In these eight cases, methotrexate was not found to be responsible for generating cancers. However, because of data regarding lymphomas and methotrexate, and because of the short follow up, especially in the control group, longer prospective studies are warranted.
Language of Publication: English
Unique Identifier: 97221235

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MeSH Heading (Major): Antirheumatic Agents|*AE; Arthritis, Rheumatoid|*DT; Methotrexate|*AE; Neoplasms|*CI/EP
MeSH Heading: Adult; Aged; Female; France|EP; Human; Incidence; Lymphoma, Non-Hodgkin|CI; Male; Middle Age; Retrospective Studies

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0003-4967
Country of Publication: ENGLAND

Record 68 from database: MEDLINE
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Title: Perimenopausal and postmenopausal hormone replacement therapy. Part 1. An update of the literature on benefits and risks [see comments]
Author: Lichtman R
Address: Columbia University School of Nursing, New York 10032, USA.
Source: J Nurse Midwifery, 1996 Jan, 41:1, 3-28
Abstract: As life expectancy increases and members of the postwar generation settle into their fifth decade of life, hormone replacement therapy--estrogen or an estrogen-progestin combination--has become a major research interest. An extensive, but often confusing and even contradictory, literature exists on the uses of hormone replacement for the treatment and prevention of a multitude of difficulties that may be associated with the perimenopausal and postmenopausal periods. These include hot flushes, vaginal changes, urinary tract changes, changes in sexuality, affective or emotional symptoms, changes in the oral mucosa and skin, loss of memory and Alzheimer's disease, bone loss and osteoporosis, and cardiovascular disease. This article reviews the literature in each of these areas. It also reviews studies relating to possible side effects of hormone therapy, including endometrial cancer, gall bladder disease, and breast cancer. The article outlines principles for practitioners to follow in assisting women to make informed and individualized decisions about this therapy. Part II of this article, which will appear in the May/June 1996 issue of the Journal of Nurse-Midwifery, will cover specific therapeutic regimens and their management, as well as alternative therapies and preventive measures.
Language of Publication: English
Unique Identifier: 96417963

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MeSH Heading (Major): Climacteric|*DE/PH; Estrogen Replacement Therapy|*/AE; Menopause|*
MeSH Heading: Adult; Aged; Alzheimer Disease|PC; Arthritis, Rheumatoid|PC; Cardiovascular Diseases|PC; Female; Human; Middle Age; Neoplasms|CI; Osteoporosis, Postmenopausal|PC; Postmenopause; Risk Factors

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0091-2182
Country of Publication: UNITED STATES

Record 69 from database: MEDLINE
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Title: Epidemiology of spinal osteoporosis.
Author: Melton LJ 3rd
Address: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Source: Spine, 1997 Dec, 22:24 Suppl, 2S-11S
Abstract: Approximately 30% of postmenopausal white women in the United States have osteoporosis, and 16% have osteoporosis of the lumbar spine in particular. Bone density of the spine is positively associated with greater height and weight, older age at menopause, a history of arthritis, more physical activity, moderate use of alcoholic beverages, diuretic treatment, and current estrogen replacement therapy, whereas later age at menarche and a maternal history of fracture are associated with lower levels of density. Low bone density leads to an increased risk of osteoporotic fractures. Fracture risk also increase with age. Vertebral fractures affect approximately 25% of postmenopausal women, although the exact figure depends on the definition used. Recent data show that vertebral fracture rates are as great in men as in women but, because women live longer, the lifetime risk of a vertebral fracture from age 50 onward is 16% in white women and only 5% in white men. Fracture rates are less in most nonwhite populations, but vertebral fractures are as common in Asian women as in those of European heritage. Other risk factors for vertebral fractures are less clear but include hypogonadism and secondary osteoporosis; obesity is protective of fractures as it is of bone loss. Compared with hip fractures, vertebral fractures are less disabling and less expensive, costing approximately $746 million in the United States in 1995. However, they have a substantial negative impact on the patient's function and quality of life. The adverse effects of osteoporotic fractures are likely to increase in the future with the growing number of elderly people.
Language of Publication: English
Unique Identifier: 98093706

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MeSH Heading (Major): Osteoporosis, Postmenopausal|EC/*EP; Spinal Diseases|EC/*EP
MeSH Heading: Aged; Aged, 80 and over; Bone Density; Female; Fractures, Spontaneous|EC/EP; Human; Lumbar Vertebrae|IN/PA; Male; Middle Age; Spinal Fractures|EP; Support, U.S. Gov't, P.H.S.; United States|EP

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0362-2436
Country of Publication: UNITED STATES

Record 70 from database: MEDLINE
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Title: Nonsteroidal anti-inflammatory drugs and acute renal failure in the elderly. A risk-benefit assessment.
Author: Ailabouni W; Eknoyan G
Address: Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Source: Drugs Aging, 1996 Nov, 9:5, 341-51
Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most valuable groups of available medications because of their effectiveness in relieving pain, particularly that associated with rheumatoid arthritis. They are also among the most commonly prescribed drugs and, because of their availability over-the-counter, they are among the most widely consumed agents, especially by elderly people. Older individuals are more predisposed to the renal adverse effects of NSAIDs, because of: (i) age-associated changes in renal function; (ii) the prevalence of comorbid conditions (congestive heart failure, hypertension, hepatic cirrhosis, renal insufficiency); and (iii) the pervasive use of concomitant drugs that affect kidney function (diuretics, antihypertensives). However, because the incidence of NSAID-induced acute renal failure (ARF) is relatively low, and because it occurs in an identifiable and therefore preventable setting, the benefits of limited NSAID use outweigh the risks of this adverse effect. Using NSAIDs for a restricted period of time at the lowest effective dosage, and informing patients of the conditions in which ARF can occur, should minimise the risk of this effect. If the use of an NSAID in a patient at potential risk of ARF is necessary, close monitoring of renal function should further reduce the already low risk:benefit ratio for this adverse effect.
Language of Publication: English
Unique Identifier: 97081316

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MeSH Heading (Major): Aging|*PH; Anti-Inflammatory Agents, Non-Steroidal|*AE/TU; Kidney Failure, Acute|*CI
MeSH Heading: Aged; Aged, 80 and over; Female; Human; Male; Middle Age; Risk Factors

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 1170-229X
Country of Publication: NEW ZEALAND

Record 71 from database: MEDLINE
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Title: Long-term results of forefoot arthroplasty in patients with rheumatoid arthritis.
Author: Patsalis T; Georgousis H; Göpfert S
Address: Department of Orthopedic Surgery, University Hospital Essen, Germany.
Source: Orthopedics, 1996 May, 19:5, 439-47
Abstract: Disabling forefoot deformity of rheumatoid origin frequently requires surgical intervention. Twenty-three patients (36 feet) who underwent excision of the metatarsal heads in our unit between 1980 and 1987 were assessed clinically and radiologically (n = 12) and by questionnaire (n = 11) at an average 10.5 years (range: 4 to 15) following surgery. Although the procedure was initially successful at the time of review, the result was classified as unsatisfactory because of restriction of walking ability due to pain in the forefoot area in 56% of patients. Recurrence of the deformity--more frequently involving the great toe--had occurred in 72% of patients, and painful callosities were present in 61%. In the patients examined clinically and radiologically, unsatisfactory results were due mainly to mal-alignment of the great toe and extensor tendon tightness. Hindfoot deformity also significantly contributed to pain in the forefoot area. Diminished arthroplasty space, irregular resection cascade, and development of bony spikes were frequently associated with recurrence and callosities. The result of forefoot arthroplasty deteriorates with time. Failure to maintain a plantigrade great toe, intrinsic weakness, and hindfoot deformity were the main factors contributing to an unsatisfactory result.
Language of Publication: English
Unique Identifier: 96328989

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MeSH Heading (Major): Arthritis, Rheumatoid|*SU; Arthroplasty|*MT; Forefoot, Human|RA/*SU
MeSH Heading: Adult; Aged; Female; Follow-Up Studies; Foot Deformities, Acquired|ET; Human; Male; Metatarsophalangeal Joint|RA/SU; Middle Age; Postoperative Complications; Treatment Failure

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, MULTICASE
ISSN: 0147-7447
Country of Publication: UNITED STATES

Record 72 from database: MEDLINE
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Title: Mycoplasma hominis septic arthritis: two case reports and review.
Author: Luttrell LM; Kanj SS; Corey GR; Lins RE; Spinner RJ; Mallon WJ; Sexton DJ
Address: Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Source: Clin Infect Dis, 1994 Dec, 19:6, 1067-70
Abstract: Mycoplasma hominis is normally a commensal of humans. When the organism is pathogenic, it primarily causes disease in the genitourinary tract. Septic arthritis caused by M. hominis is a rare condition that occurs chiefly in the postpartum period, in immunosuppressed hosts, or in patients who have recently undergone urinary tract manipulation. Arthritis caused by M. hominis is clinically indistinguishable from septic arthritis caused by other bacteria. Diagnosis is often delayed because infection with this organism is not suspected or because it grows slowly, if at all, in routine culture media. Appropriate therapy often leads to a good outcome, although relapses and resistance have been reported.
Language of Publication: English
Unique Identifier: 95195071

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MeSH Heading (Major): Arthritis, Infectious|DI/DT/*MI; Mycoplasma Infections|*/DI/DT/MI
MeSH Heading: Aged; Case Report; Doxycycline|TU; Fatal Outcome; Female; Human; Joint Diseases|MI; Knee Joint; Male; Middle Age; Mycoplasma|IP; Shoulder Joint; Synovial Fluid|MI

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 1058-4838
Country of Publication: UNITED STATES

Record 73 from database: MEDLINE
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Title: Diagnostic arthroscopy in the arthritis patient.
Author: ORourke KS; Ike RW
Address: Department of Internal Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Source: Rheum Dis Clin North Am, 1994 May, 20:2, 321-42
Abstract: The arthroscope can play an important diagnostic role in the arthritis patient. The major utility of this procedure is in the patient with unexplained knee pain and swelling or in the patient with an established knee arthritis whose symptoms are disproportionate to radiographic findings or refractory to standard-course medical therapy. Technologic advances have led to the production of smaller instruments, making office-based diagnostic arthroscopy a practical, cost-effective alternative in the evaluation of these patients, and supporting the clinical argument for it as a procedure distinct from conventional arthroscopy. Separate clinical scenarios further subdivide the indications for diagnostic arthroscopy and define potential intra-articular abnormalities that, if found, can justify alterations in or additions to therapeutic plans, including arthroscopically directed tissue resection and modification or application of tissue-modifying agents. The research capabilities of needle arthroscopy are only just beginning to be realized; opportunities now exist for design of prospective clinical trials in which patients are randomized based on intra-articular abnormalities, and for the serial assessment of specific treatment effects on gross, microscopic, and molecular features of target tissue as identified by the arthroscope.
Language of Publication: English
Unique Identifier: 94286900

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MeSH Heading (Major): Arthritis|*DI; Arthroscopy|*/IS
MeSH Heading: Adult; Arthritis, Rheumatoid|DI; Case Report; Diagnosis, Differential; Female; Human; Knee Joint|PA; Male; Middle Age

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0889-857X
Country of Publication: UNITED STATES

Record 74 from database: MEDLINE
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Title: Septic arthritis: Arthroscopic management with local antibiotic treatment.
Author: Jerosch J; Hoffstetter I; Schröder M; Castro WH
Address: Orthopedic Department, WestfÂalische-Wilhelms University MÂunster, Germany.
Source: Acta Orthop Belg, 1995, 61:2, 126-34
Abstract: In a retrospective study, the results of arthroscopic treatment of septic arthritis were evaluated in 12 patients. Ages ranged from 4 to 57 years. The knee joint was affected in 9 cases, the elbow in 2 cases, and the shoulder joint in one case. In 3 patients the infection was hematogenous. Four patients had a postoperative infection and in 5 patients the infection followed an intraarticular injection. The indication for arthroscopic treatment was based on clinical findings, an increased ESR and/or CRP, an increase in leukocyte count in the joint fluid and no bone involvement on x-ray. Arthroscopic management was performed according to the intraoperative findings (lavage, debridement, synovectomy). The procedure was completed by intraarticular placement of an antibiotic collagenous fleece. Additionally systemic antibiotics, active against staphylococcus aureus, were used for perioperative therapy before starting a specific antibiotic treatment according to the cultured organism. In 10 out of 12 cases the infection was cured by one operation. Because of the advantages of arthroscopic treatment, it should be performed as soon as joint infection is confirmed.
Language of Publication: English
Unique Identifier: 95321085

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MeSH Heading (Major): Arthritis, Infectious|ET/MI/*SU; Knee Joint|*
MeSH Heading: Adult; Antibiotics|AD; Arthroscopy|MT; Child; Child, Preschool; Debridement; Female; Human; Irrigation; Male; Middle Age; Retrospective Studies; Synovial Membrane|SU

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0001-6462
Country of Publication: BELGIUM

Record 75 from database: MEDLINE
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Title: Multifocal cellulitis and monoarticular arthritis as manifestations of Helicobacter cinaedi bacteremia.
Author: Burman WJ; Cohn DL; Reves RR; Wilson ML
Address: Medical Laboratories, Denver Department of Health and Hospitals, Colorado 80204, USA.
Source: Clin Infect Dis, 1995 Mar, 20:3, 564-70
Abstract: Helicobacter cinaedi (formerly Campylobacter cinaedi) was first detected in the fecal flora of homosexual men. Since 1984, 11 case reports of H. cinaedi bacteremia have been published; most cases have presented as a nonspecific febrile illness in homosexual men infected with the human immunodeficiency virus (HIV). We identified seven additional cases of H. cinaedi bacteremia in two Denver hospitals within a 5-year period, which suggests that this illness is not as rare as was previously thought. Six of these cases of H. cinaedi bacteremia occurred in homosexual men who were infected with HIV. Four patients presented with the distinctive cutaneous manifestation of multifocal cellulitis, and two patients had monoarticular arthritis. Microbiological diagnosis of this infection was delayed by the slow growth of the bacterium in nonradiometric blood culture bottles. Although the patients' bacteremia was prolonged, their response to treatment was excellent. In contrast to campylobacter infections in HIV-infected patients, H. cinaedi bacteremia did not relapse after a course of effective therapy. H. cinaedi bacteremia should be suspected in HIV-infected individuals who present with an indolent febrile illness, particularly in the presence of multifocal cellulitis and/or arthritis.
Language of Publication: English
Unique Identifier: 95276056

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MeSH Heading (Major): Arthritis, Infectious|DT/*MI; Bacteremia|*PP; Cellulitis|DT/*MI; Helicobacter Infections|*PP
MeSH Heading: Adult; AIDS-Related Opportunistic Infections|DT/PP; Case Report; Child, Preschool; Ciprofloxacin|TU; Dicloxacillin|TU; Doxycycline|TU; Female; Follow-Up Studies; Human; Male; Middle Age

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 1058-4838
Country of Publication: UNITED STATES

Record 76 from database: MEDLINE
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Title: Sulphasalazine-induced autoimmune abnormalities in patients with rheumatic disease [see comments]
Author: Laversuch CJ; Collins DA; Charles PJ; Bourke BE
Address: Department of Rheumatology, St George's Hospital, London.
Source: Br J Rheumatol, 1995 May, 34:5, 435-9
Abstract: Sulphasalazine is a commonly used second line agent in rheumatoid arthritis (RA) and other inflammatory joint diseases and is reported to be one of the least toxic of this group of drugs. Recently a severe allergic reaction and cases of lupus-like disease have been described in patients with RA after treatment with sulphasalazine. We describe five patients, all with inflammatory arthropathy who developed cutaneous vasculitis, lupus-like disease or atypical serology after exposure to sulphasalazine. Three of four cases investigated were found to have the slow acetylator phenotype. These reactions can complicate the diagnosis and delay discontinuation of the drug. Moreover, present guidelines for the diagnosis of drug-induced lupus do not apply to the majority of patients with sulphasalazine-induced lupus.
Language of Publication: English
Unique Identifier: 95307914

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MeSH Heading (Major): Arthritis, Rheumatoid|DT/*IM; Autoimmune Diseases|*CI; Autoimmunity|*DE; Sulfasalazine|*AE/TU
MeSH Heading: Adult; Case Report; Female; Human; Lupus Erythematosus, Systemic|CI; Male; Middle Age; Vasculitis, Allergic Cutaneous|CI

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0263-7103
Country of Publication: ENGLAND

Record 77 from database: MEDLINE
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Title: Silica-associated connective tissue disease. A study of 24 cases.
Author: Koeger AC; Lang T; Alcaix D; Milleron B; Rozenberg S; Chaibi P; Arnaud J; Mayaud C; Camus JP; Bourgeois P
Address: Department of Rheumatology, HÈopital PitiÆe-SalpÈetriÄere, Paris, France.
Source: Medicine (Baltimore), 1995 Sep, 74:5, 221-37
Abstract: We prospectively studied all patients hospitalized for connective tissue disease (CTD) in our French rheumatology clinic from January 1979 to December 1989. Our aims were 1) to determine if CTDs associated with occupational exposure to silica (Si) are currently observed in a rheumatology clinic, and, if so, 2) to describe the major features of Si-associated CTD, and 3) to specify which individuals are affected by Si-associated CTD. Patients were divided into 2 groups based on their responses to a questionnaire: those who had been exposed to Si, and those who had no occupational exposure to Si. Among the 764 patients with CTD studied, 24 (3%) were patients with Si-associated CTD and 740 (97%) were patients with non-Si-associated CTD. The sex ratio between the 2 groups was significantly different with a high frequency of men and of immigrants in the Si-associated CTD group. Two thirds of the patients exposed to Si were male miners or sandblasters, but the other third had more unusual exposures to Si, which may involve members of all socio-economics sectors and both sexes, such as sculpture or exposure to abrasive powders. Progressive systemic sclerosis (PSS) was significantly more prevalent in the Si-associated CTD group. This group also consisted of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), dermatomyositis (DM), and other autoimmune diseases. Si-associated CTD was characterized by the frequency of radiologic lung fibrosis, impaired pulmonary function tests, secondary Sjögren syndrome, and antinuclear antibodies. The number of mineral particles and crystalline Si content were raised in all the bronchoalveolar lavage specimens of Si-exposed patients but in none of those of nonexposed patients. In some cases of Si-associated CTD, the disease was reversible after early cessation of Si exposure. Epidemiologic studies are required to confirm our hypothesis that not only PSS and RA but also SLE and DM are associated with occupational exposure to Si. Pending such results, exposure to Si should be sought in the history of any patient with CTD, especially in a male patient with pulmonary signs, and if present, exposure should be stopped. In the meantime, steps should be taken to ensure that workers exposed to Si in all environments have adequate protection.
Language of Publication: English
Unique Identifier: 96013366

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MeSH Heading (Major): Connective Tissue Diseases|DI/*ET; Silicon Dioxide|*AE/BL
MeSH Heading: Adult; Arthritis, Rheumatoid|ET; Cross-Sectional Studies; Female; Human; Male; Middle Age; Occupational Diseases|PC; Occupational Exposure; Occupational Health; Prospective Studies; Pulmonary Fibrosis|ET

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0025-7974
Country of Publication: UNITED STATES

Record 78 from database: MEDLINE
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Title: Gout or 'pseudogout': how to differentiate crystal-induced arthropathies.
Author: Joseph J; McGrath H
Address: Department of Medicine, Louisiana State University Medical Center, New Orleans, USA.
Source: Geriatrics, 1995 Apr, 50:4, 33-9
Abstract: Gout is an inflammatory joint disease that primarily affects middle-aged men and postmenopausal women. It is characterized by severe pain and erythema in the big toe and other affected joints. Acute gout may be triggered by diuretics, aspirin, minor trauma, or acute illness. The presence of monosodium urate crystals within phagocytes from synovial fluid aspirates is almost always diagnostic. Calcium pyrophosphate deposition disease ("pseudogout") usually affects larger joints and often follows trauma, surgery, or ischemic heart disease. Microscopic examination of crystals under compensated polarized light is used to differentiate gout and pseudogout. Disorders involving basic calcium phosphate are often more difficult to diagnose and treat but are also less likely to be disabling.
Language of Publication: English
Unique Identifier: 95237632

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MeSH Heading (Major): Arthritis, Gouty|*DI/DT; Chondrocalcinosis|*DI/DT; Gout|*DI/DT
MeSH Heading: Adult; Calcium Phosphates|AN; Calcium Pyrophosphate|AN; Diagnosis, Differential; Female; Human; Male; Middle Age; Uric Acid|BL

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0016-867X
Country of Publication: UNITED STATES

Record 79 from database: MEDLINE
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Title: The dermatologist and workers' compensation. Theory and practice.
Author: Adams RM
Address: Department of Dermatology, Stanford University School of Medicine, California.
Source: Dermatol Clin, 1994 Jul, 12:3, 583-9
Abstract: Workers' compensation law is poorly understood by many physicians, including dermatologists. The tenets of this law throughout the country are basic and fairly straight forward, and the most important of them are nearly the same for all of the states. By understanding how the law operates and what is required of physicians, helping patients with their work-related dermatoses can be a gratifying experience.
Language of Publication: English
Unique Identifier: 95008424

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MeSH Heading (Major): Dermatitis, Occupational|*/ET; Dermatology|*/LJ; Workers' Compensation|*/LJ
MeSH Heading: Adult; Arthritis, Psoriatic|ET; Case Report; Dermatitis, Allergic Contact|ET; Female; Human; Male; Middle Age; Occupational Exposure; Urticaria|ET

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0733-8635
Country of Publication: UNITED STATES

Record 80 from database: MEDLINE
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Title: The impact of arthritis in rural populations.
Author: Jordan JM; Linder GF; Renner JB; Fryer JG
Address
Source: Arthritis Care Res, 1995 Dec, 8:4, 242-50
Abstract: OBJECTIVE: Rural residents may experience more arthritis and disability than urban dwellers. This paper reviews data on arthritis in rural areas and describes a new study, the Johnston County Osteoarthritis Project, a population-based study of osteoarthritis [OA] of the knee and hip in rural North Carolina. METHODS: Published reports of urban and rural comparisons of arthritis were reviewed. Data from the first 1,432 African-American and Caucasian participants in the Johnston County Osteoarthritis Project were analyzed. Radiographic knee and hip OA were defined as a Kellgren-Lawrence grade > or = 2. Functional ability was assessed by the Health Assessment Questionnaire, timed chair stands, and 8-foot walk time. Unweighted prevalences of knee and hip OA were calculated for age, sex, and racial groups. Associations between hip and knee OA, and hip and knee pain and functional ability were examined. RESULTS: Hip OA was present in 27.9% and knee OA in 38.4% of participants. Both were strongly related to age (P < 0.0001), but only knee OA to female sex (odds ratio = 1.33, 95% confidence interval 1.05, 1.68). Neither hip OA nor knee OA was related to race. Hip OA, hip pain, knee OA, and knee pain was each associated with self-reported and observed functional ability. CONCLUSION: Residents in rural areas may experience more arthritis and disability than previously expected. Contrary to other studies, African-American and Caucasian residents of rural Johnston County, North Carolina, have similar high rates of knee and hip OA. Further study is needed to address urban/rural differences in arthritis and its impact, with adequate control of confounders, standard definitions of rural/urban and of disease, and assessment of multiple arthritis outcomes.
Language of Publication: English
Unique Identifier: 96193481

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MeSH Heading (Major): Arthritis|*EP; Rural Health|*
MeSH Heading: Activities of Daily Living; Aged; Comparative Study; Female; Human; Male; Middle Age; Population Surveillance; Prevalence; Questionnaires; Risk Factors; Support, U.S. Gov't, Non-P.H.S.; Support, U.S. Gov't, P.H.S.; United States|EP; Urban Health

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0893-7524
Country of Publication: UNITED STATES

Record 81 from database: MEDLINE
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Title: Bronchiolitis obliterans organizing pneumonia.
Author: Epler GR
Address: Department of Medicine, New England Baptist Hospital, Boston, MA 02120, USA.
Source: Semin Respir Infect, 1995 Jun, 10:2, 65-77
Abstract: Bronchiolitis obliterans organizing pneumonia (BOOP) is increasingly recognized as an important cause of diffuse infiltrative lung disease. It is a diagnostic consideration in patients with a febrile flu-like illness of a few weeks' duration and a roentgenogram showing bilateral patchy infiltrates that are not responsive to a typical course of antibiotics. It is defined as granulated tissue plugs within lumens of small airways that extend into alveolar ducts and alveoli. Clinically, a flu-like illness, cough, and crackles are common. Pulmonary function studies of patients show a decreased vital capacity, normal flow rates (except in smokers), and a decreased diffusing capacity. It is generally idiopathic, but it may occur during the resolution of a viral or mycoplasma pneumonia. It is also associated with a variety of systemic illnesses and clinical settings. These include the connective tissue disorders, antineoplastic and other drugs, and immunological disorders, as well as bone marrow and lung transplantation. There are numerous related disorders, including human immunodeficiency virus infection, radiation therapy, thyroiditis, and alcoholic cirrhosis. In idiopathic BOOP, complete resolution occurs in 65% to 85% of patients treated with corticosteroid therapy. This type of therapy is often effective in patients with associated systemic disorders or in other clinical settings, but there may be limited or no response in patients with dermatomyositis, immunosuppression, or interstitial opacities at the lung bases. Respiratory failure leading to death may occur in 5% of patients. It is important to add BOOP to the differential diagnosis of febrile, noninfectious illnesses that are mimics of pneumonia.
Language of Publication: English
Unique Identifier: 96047398

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MeSH Heading (Major): Bronchiolitis Obliterans Organizing Pneumonia|CL/*DI/ET
MeSH Heading: Adult; Arthritis, Rheumatoid|CO; Bone Marrow Transplantation|AE; Connective Tissue Diseases|CO; Diagnosis, Differential; Female; Human; Immunologic Diseases|CO; Lung|PA; Lung Transplantation|AE; Male; Middle Age; Pneumonia|DI; Pneumonia, Mycoplasma|CO; Pneumonia, Viral|CO; Radiography, Thoracic; Tomography, X-Ray Computed

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0882-0546
Country of Publication: UNITED STATES

Record 82 from database: MEDLINE
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Title: Pseudoporphyria due to naproxen. A cluster of 3 cases.
Author: Creemers MC; Chang A; Franssen MJ; Fiselier TJ; van Riel PL
Address: Dept rheumatology, University Hospital Nijmegen, The Netherlands.
Source: Scand J Rheumatol, 1995, 24:3, 185-7
Abstract: Pseudoporphyria is a photo-induced blistering disorder with increased skin fragility, caused among others by nonsteroidal antiinflammatory drugs. Lesions heal with scarring and milia. Porphyrin screen studies are normal in this disease. Histology and immunofluorescence resembles porphyria cutanea tarda. In this report we describe a cluster of three cases of naproxen-induced pseudoporphyria, and review briefly previously reported cases induced by naproxen. The majority of reported cases involve children. Physicians should be aware of this reversible skin disorder.
Language of Publication: English
Unique Identifier: 95296667

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MeSH Heading (Major): Naproxen|*AE; Porphyria|*CI
MeSH Heading: Adult; Arthritis|DT; Child; Female; Human; Male; Middle Age; Support, Non-U.S. Gov't

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0300-9742
Country of Publication: NORWAY

Record 83 from database: MEDLINE
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Title: The variable clinical picture of arthritis induced by human parvovirus B19. Report of seven adult cases and review of the literature.
Author: Gran JT; Johnsen V; Myklebust G; Nordb‡ SA
Address: Department of rheumatology, Central Hospital of Aust-Agder, Arendal, Norway.
Source: Scand J Rheumatol, 1995, 24:3, 174-9
Abstract: Seven patients with arthritis due to infection with human parvovirus B19 are reported, and the literature association reviewed. B19 virus arthritis most frequently affects young to middle aged women and occurs predominantly during the first six months of the year. The majority of cases have oligoarthritis or polyarthritis, and the joints most often involved are the proximal interphalangeal joints and knees. Of the seven patients reported, one case developed systemic lupus erythematosus, one case evolved into erosive, seropositive rheumatoid arthritis while one case was subsequently diagnosed as undifferentiated connective tissue disease.
Language of Publication: English
Unique Identifier: 95296664

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MeSH Heading (Major): Arthritis, Infectious|*VI; Erythema Infectiosum|CO/*DI; Parvovirus B19, Human|*
MeSH Heading: Adult; Diagnosis, Differential; Female; Human; Male; Middle Age

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0300-9742
Country of Publication: NORWAY

Record 84 from database: MEDLINE
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Title: Total ankle arthroplasty. Indications, techniques, and results.
Author: Lachiewicz PF
Address: University of North Carolina School of Medicine, Chapel Hill.
Source: Orthop Rev, 1994 Apr, 23:4, 315-20
Abstract: A high rate of complications and failure have limited the indications for total ankle replacement to older patients with rheumatoid arthritis, especially those with multiple joint involvement and limited physical activity. Recommended surgical technique for total ankle arthroplasty includes proper patient positioning, an anterior surgical approach, meticulous bone resection, and cemented fixation of components. Results of published studies suggest total ankle arthroplasty should not be performed in patients with posttraumatic arthritis who are younger than 60 years of age.
Language of Publication: English
Unique Identifier: 94277638

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MeSH Heading (Major): Ankle Joint|RA/*SU; Arthritis|*SU; Joint Prosthesis|*
MeSH Heading: Aged; Arthroplasty|MT; Follow-Up Studies; Human; Middle Age; Postoperative Complications|ET; Prosthesis Design

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0094-6591
Country of Publication: UNITED STATES

Record 85 from database: MEDLINE
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Title: Chronic immunity-driven polyarthritis in hairy cell leukemia. Report of a case and review of the literature.
Author: Vernhes JP; Schaeverbeke T; Fach J; Lequen L; Bannwarth B; Dehais J
Address: Rheumatology Department, Pellegrin- Tondu Hospital, Bordeaux, France.
Source: Rev Rhum Engl Ed, 1997 Oct, 64:10, 578-81
Abstract: Hairy cell leukemia can be responsible for polyarthritis due either to leukemic infiltration or to immunity-drive inflammation. The second variant can antedate or post-date the clinical onset of leukemic symptoms and usually presents as rheumatoid arthritis, more rarely as lupus or scleroderma. The presence of hairy cells in the joint fluid does not rule out autoimmune polyarthritis. The main differential diagnoses are Felty's syndrome and large granular lymphocyte leukemia. We report a case of hairy cell leukemia with seropositive rheumatoid arthritis.
Language of Publication: English
Unique Identifier: 98046805

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MeSH Heading (Major): Arthritis, Rheumatoid|DT/*ET/IM; Leukemia, Hairy Cell|*CO/DT
MeSH Heading: Aged; Aged, 80 and over; Antibodies, Antinuclear|AN; Antineoplastic Agents|TU; B-Lymphocytes|IM/PA; C-Reactive Protein|AN; Case Report; Diagnosis, Differential; Glucocorticoids, Synthetic|TU; Human; Immunity; Interferon Alfa-2b|TU; Male; Prednisone|TU; Rheumatoid Factor|AN; Synovial Fluid|CY

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0035-2659
Country of Publication: FRANCE

Record 86 from database: MEDLINE
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Title: Could diet be used to reduce the risk of developing Alzheimer's disease?
Author: Newman PE
Address
Source: Med Hypotheses, 1998 Apr, 50:4, 335-7
Abstract: Researchers have recently reported a possible inverse relationship between taking steroids or non-steroidal anti-inflammatory drugs, or both, and the development of Alzheimer's disease. In this article it is hypothesized that the reduction in the human body of the amount of available arachidonic acid, the precursor of inflammatory eicosanoids, by dietary methods might offer a path to prevention of Alzheimer's disease without resorting to drugs having potentially harmful side effects, and without inhibiting the production of highly important, non-inflammatory eicosanoids.
Language of Publication: English
Unique Identifier: 98353080

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MeSH Heading (Major): Alzheimer Disease|CO/*PC; Diet|*; Models, Biological|*
MeSH Heading: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal|TU; Arthritis, Rheumatoid|CO/DT; Fatty Acids, Essential|PH; Female; Human; Male

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0306-9877
Country of Publication: ENGLAND
CAS Registry/EC Number: 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Fatty Acids, Essential)

Record 87 from database: MEDLINE
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Title: A comparison of osteoarthritis and rheumatoid arthritis: diagnosis and treatment.
Author: Ross C
Address
Source: Nurse Pract, 1997 Sep, 22:9, 20, 23-4, 27-8 passim; quiz 39-41
Abstract: Arthritis is one of the most common chronic illnesses managed in primary care. Osteoarthritis and rheumatoid arthritis are two common types the provider must distinguish between in terms of diagnosis and treatment. Osteoarthritis, the most common form, typically occurs in people more than 60 years of age and involves cartilage destruction. Signs and symptoms are local and include cool, bony joints and arthralgia that worsens with weight bearing. Treatment includes acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), exercise, and joint arthroplasty in severe cases. Rheumatoid arthritis is a systemic disease that results in symmetrical joint inflammation along with constitutional symptoms such as fatigue and depression. Current treatment recommendations include early use of disease modifying anti-rheumatic drugs along with NSAIDs. The key to arthritis management is early diagnosis and treatment to prevent further joint destruction and maximize functional ability.
Language of Publication: English
Unique Identifier: 97459392

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MeSH Heading (Major): Arthritis, Rheumatoid|*/DI/DT/EP/ET/PX/RH; Osteoarthritis|*/DI/DT/EP/ET/PX/RH
MeSH Heading: Aged; Diagnosis, Differential; Human; Middle Age; Patient Education; United States|EP

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0361-1817
Country of Publication: UNITED STATES

Record 88 from database: MEDLINE
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Title: Alzheimer's disease risk factors as related to cerebral blood flow.
Author: Crawford JG
Address: Indiana University School of Medicine, Terre Haute Center for Medical Science, IN 47809, USA.
Source: Med Hypotheses, 1996 Apr, 46:4, 367-77
Abstract: Inconsistencies within results of case-control studies on Alzheimer's disease risk factors led to a search of the literature for a potential cofactor. Reduced cerebral blood flow was selected and literature was surveyed for evidence of a cerebral blood flow linkage with the more than 40 putative risks. Alcohol abuse, depression, head trauma, underactivity, old age, sleep disturbance, glucose utilization, Down's syndrome, and Parkinson's disease are risk factors where an association with reduced cerebral blood flow is documented. Studies were cited showing that improved cerebral blood flow is associated with factors thought to be helpful in Alzheimer's disease, such as education or occupational attainment, exercise, headache, smoking, and arthritis/anti-inflammatory drugs to the extent that aspirin is used. Sugar consumption is identified as a potential risk factor with glucose management in Alzheimer's disease also shown to involve reduced cerebral blood flow. An hypothesis is developed showing how compromised regional cerebral blood flow could fit as a cofactor for genetic, autoimmune, and neurotoxic aspects of Alzheimer's disease.
Language of Publication: English
Unique Identifier: 96310331

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MeSH Heading (Major): Alzheimer Disease|*ET/PC/*PP; Cerebrovascular Circulation|*
MeSH Heading: Aged; Aged, 80 and over; Aging|PH; Alcoholism|CO/PP; Arthritis|PP; Depression|CO/PP; Down Syndrome|CO/PP; Educational Status; Exercise; Glucose|ME; Head Injuries|CO/PP; Headache|PP; Human; Models, Neurological; Parkinson Disease|CO/PP; Risk Factors; Sleep Disorders|CO/PP; Smoking|PP

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, ACADEMIC
ISSN: 0306-9877
Country of Publication: ENGLAND

Record 89 from database: MEDLINE
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Title: Monarthritis: differential diagnosis.
Author: Sack K
Address: Department of Medicine, University of California, San Francisco 94143-0326, USA.
Source: Am J Med, 1997 Jan, 102:1A, 30S-34S
Abstract: Acute monarthritis should be regarded as infectious until proved otherwise. Early evaluation is crucial because of the capacity of some infectious agents to destroy cartilage rapidly. The history and physical examination can provide highly suggestive clues, but a definitive diagnosis may depend on arthrocentesis and analysis of synovial fluid. The diagnosis of acute monarthritis is rarely established by radiography. The most common cause of bacterial arthritis is Neisseria gonorrhoeae. Staphylococcus aureus and streptococci are the organisms most frequently implicated in nongonococcal bacterial arthritis, although the possibility of Gram-negative bacteria or anaerobes should not be overlooked in intravenous drug users or immunocompromised patients. Inflammation in a large joint, particularly the knee, might arouse suspicion of Lyme disease. Other, less frequently encountered infectious causes of acute monarthritis include tuberculosis and other mycobacteria, fungi, and viruses. Arthroscopic examination and synovial tissue biopsy may be necessary to diagnose such processes. Microscopic examination of the synovial fluid may reveal a crystalline etiology for monarthritis. Monosodium urate crystals induce gout, usually in the toe, ankle, or midfoot, while calcium pyrophosphate crystals cause pseudogout, most often in the knee or wrist. Acute monarthritis is sometimes a manifestation of osteoarthritis or an early sign of a systemic arthritis such as rheumatoid or reactive arthritis. Processes underlying acute monarthritis can also evolve into a more chronic clinical picture as exemplified by the spondyloarthropathies.
Language of Publication: English
Unique Identifier: 97360593

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MeSH Heading (Major): Arthritis|*DI/*ET/ME/MI; Synovial Fluid|*/CH/MI
MeSH Heading: Acute Disease; Adult; Arthritis, Infectious|DI/ET; Case Report; Chronic Disease; Crystallization; Diagnosis, Differential; Female; Human; Male; Middle Age; Osteoarthritis|DI/ET; Paracentesis

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0002-9343
Country of Publication: UNITED STATES

Record 90 from database: MEDLINE
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Title: Septic arthritis.
Author: Pioro MH; Mandell BF
Address: Division of General Internal Medicine and Health Care Research, University Hospitals of Cleveland, Ohio, USA.
Source: Rheum Dis Clin North Am, 1997 May, 23:2, 239-58
Abstract: Septic arthritis is a medical emergency that can lead to significant morbidity and mortality. Prompt recognition and treatment are critical to ensuring a good prognosis. Thus, this article reviews the clinical presentation, microbiology, diagnostic workup, and outcome of nonprosthetic joint infections.
Language of Publication: English
Unique Identifier: 97301371

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MeSH Heading (Major): Arthritis, Infectious|*/DI/ET/TH; Joint Diseases|DI/*MI/TH
MeSH Heading: Aged; Antibiotics|TU; Bacterial Infections|CO; Child, Preschool; Female; Human; Male; Middle Age; Risk Factors; Synovial Membrane|MI/PA

Publication Type: JOURNAL AICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0889-857X
Country of Publication: UNITED STATES

Record 91 from database: MEDLINE
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Title: Psoriatic and seronegative inflammatory arthropathy associated with a traumatic onset: 4 cases and a review of the literature.
Author: Sandorfi N; Freundlich B
Address: Department of Medicine, Graduate Hospital, Philadelphia, PA 19146, USA.
Source: J Rheumatol, 1997 Jan, 24:1, 187-92
Abstract: Although a relationship between psoriatic arthritis or other spondyloarthropathies and trauma is discussed in the literature and rheumatology textbooks, there are few well documented case reports that substantiate this association. We describe 3 patients who developed psoriatic arthritis and a 4th who developed unilateral spondyloarthropathy rapidly after trauma. The argument that the arthritis in these cases was precipitated by trauma rests upon the contiguous sequential temporal relationship between the 2 events and the onset of arthritis (and psoriasis) at the sites of trauma.
Language of Publication: English
Unique Identifier: 97155320

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MeSH Heading (Major): Arthritis, Psoriatic|*ET; Wounds and Injuries|*CO
MeSH Heading: Adolescence; Adult; Arthritis|BL/ET; Female; Human; Male; Middle Age; Reiter's Disease; Sacroiliac Joint|PA

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0315-162X
Country of Publication: CANADA

Record 92 from database: MEDLINE
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Title: High dose intravenous immunoglobulin therapy for rheumatic diseases: clinical relevance and personal experience.
Author: De Vita S; Ferraccioli GF; Di Poi E; Bartoli E; Bombardieri S
Address: Department of Internal Medicine, University of Udine, Italy.
Source: Clin Exp Rheumatol, 1996 May, 14 Suppl 15:, S85-92
Abstract: The actual efficacy and applicability of high dose intravenous immunoglobulin (IVIG) therapy in the rheumatic disorders is still being debated. In the last few years clinical results have become available on a large number of patients, and efforts have been devoted to experimental studies of the mechanism of action of IVIG. However, the results of controlled clinical trials will be crucial to indicate stricter guidelines and directions for future clinical and experimental research. IVIG is of major value in Kawasaki disease and in severe lupus-associated thrombocytopenia. Its possible benefits are also remarkable in refractory dermatomyositis and probably in some patients with the antiphospholipid syndrome and recurrent miscarriages despite standard treatment. At present, the role of IVIG therapy remains controversial in lupus nephritis and in systemic vasculitis, while it does not seem to be effective in rheumatoid arthritis.
Language of Publication: English
Unique Identifier: 96426674

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MeSH Heading (Major): Immunoglobulins, Intravenous|*TU
MeSH Heading: Adolescence; Adult; Antiphospholipid Syndrome|DT; Arthritis, Juvenile Rheumatoid|DT; Female; Human; Lupus Erythematosus, Systemic|DT; Male; Middle Age; Myositis|DT; Rheumatic Diseases; Still's Disease, Adult-Onset|DT; Vasculitis|DT

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0392-856X
Country of Publication: ITALY

Record 93 from database: MEDLINE
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Title: The impact of musculoskeletal disorders on the population of the United States.
Author: Kelsey JL; White AA 3d; Pastides H; Bisbee GE Jr
Address
Source: J Bone Joint Surg [Am], 1979 Oct, 61:7, 959-64
Abstract: Musculoskeletal disorders constitute such a large component of impairments of individuals in the working and geriatric population that good statistical data on them are essential for planning health care. We have collected the pertinent data, with references to recent source material, to determine the incidence, effect on the quality of life, and associated costs of these disorders in the United States.
Language of Publication: English
Unique Identifier: 80027474

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MeSH Heading (Major): Bone Diseases|EC/*EP; Muscular Diseases|EC/*EP
MeSH Heading: Adult; Aged; Arthritis|EP; Back Pain|EP; Female; Fractures|EP; Human; Male; Middle Age; Osteoporosis|EP; Quality of Life; Spinal Cord Injuries|EP; Support, U.S. Gov't, P.H.S.; United States; Workers' Compensation

Publication Type: JOURNAL ARTICLE; REVIEW
ISSN: 0021-9355
Country of Publication: UNITED STATES

Record 94 from database: MEDLINE
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Title: Psoriatic arthritis and hypopyon-iridocyclitis. Possible mechanism of the association of psoriasis and anterior uveitis.
Author: Iijima S; Iwata M; Otsuka F
Address: Department of Dermatology, University of Tsukuba, Japan.
Source: Dermatology, 1996, 193:4, 295-9
Abstract: BACKGROUND: We present a 32-year-old Japanese man with psoriatic arthritis who developed recurrent episodes of hypopyon-iridocyclitis associated with exacerbations of the arthropathy. OBJECTIVE: To evaluate the mechanism of the association between psoriasis and uveitis, we analyzed the rheological characteristics of the patient's peripheral blood neutrophils during attacks and during remissions. METHODS: The rheological activity of neutrophils was determined by the micropore filtration method. It was expressed as micropore filtration time when a neutrophil-erythrocyte suspension passes through a micropore filter (pore size 5 microns). RESULTS: The micropore filtration time in this patient was longer than that of healthy control subjects (p < 0.01) and of psoriatic patients without uveitis (p < 0.05); it was also longer during the appearance of the eye disorder with the exacerbation of psoriatic arthritis than during remissions. CONCLUSIONS: Activated neutrophils in the peripheral blood of our patient were probably responsible for the attacks of hypopyon-iridocyclitis as well as the exacerbation of psoriatic skin lesions and/or arthritis.
Language of Publication: English
Unique Identifier: 97147096

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MeSH Heading (Major): Arthritis, Psoriatic|*CO/DI/PP; Iridocyclitis|*CO/*DI/PP; Neutrophils|*ME
MeSH Heading: Adult; Case Report; Female; Human; Male; Middle Age; Reference Values; Rheology|MT

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 1018-8665
Country of Publication: SWITZERLAND

Record 95 from database: MEDLINE
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Title: Hyperimmunoglobulinemia D and periodic fever syndrome. The clinical spectrum in a series of 50 patients. International Hyper-IgD Study Group.
Author: Drenth JP; Haagsma CJ; van der Meer JW
Address: Department of Medicine, University Hospital St Radboud, Nijmegen, The Netherlands.
Source: Medicine (Baltimore), 1994 May, 73:3, 133-44
Abstract: We studied 50 patients (28 male and 22 female) with the hyper-IgD and periodic fever syndrome. Most patients originated from Europe, namely The Netherlands (28 cases; 56%), France (10 cases, 20%), and Italy (3 cases, 6%), but 1 patient was from Japan. A hereditary component is suggested by 18 patients coming from 8 families. The syndrome is typified by a very early age at onset (median, 0.5 years) and life-long persistence of periodic fever. Characteristically, attacks occur every 4-8 weeks and continue for 3-7 days, but the individual variation is large. Attacks feature high spiking fever, preceded by chills in 76% of patients. Lymphadenopathy is commonly present (94% of patients). During attacks, 72% of patients complained of abdominal pains, 56% of vomiting, 82% of diarrhea, and 52% of headache. Joint involvement is common in the hyper-IgD syndrome with poly-arthralgia in 80% and a non-destructive arthritis, mainly of the large joints (knee and ankle), in 68% of patients. Eighty-two percent of patients reported skin lesions with some attacks; these demonstrated vasculitis histologically. Serositis has been seen in only 3 patients (6%), while amyloidosis has not been recorded in any of the patients with this syndrome. Immunizations precipitated attacks in 54% of patients. All patients had a persistently elevated serum IgD level (> 100 U/mL), and in 82% of cases the serum IgA was likewise elevated. During attacks there is an acute-phase response adjudged by leukocytosis, neutrophilia, and increased ESR. The etiology remains to be elucidated, and treatment is supportive. The hyper-IgD syndrome is distinct from other periodic fever syndromes like systemic-onset juvenile rheumatoid arthritis, adult-onset Still disease, and familial Mediterranean fever.
Language of Publication: English
Unique Identifier: 94247290

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MeSH Heading (Major): Fever|*DI/IM; Hypergammaglobulinemia|*DI/IM; IgD|*AN/IM; Periodic Disease|*DI/IM
MeSH Heading: Adolescence; Adult; Age of Onset; Aged; Child; Child, Preschool; Female; Human; Male; Middle Age; Prognosis; Splenomegaly|DI/IM; Support, Non-U.S. Gov't; Syndrome

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0025-7974
Country of Publication: UNITED STATES

Record 96 from database: MEDLINE
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Title: Musculoskeletal infections in patients with human immunodeficiency virus infection.
Author: Vassilopoulos D; Chalasani P; Jurado RL; Workowski K; Agudelo CA
Address: Emory University School of Medicine, Atlanta, Georgia, USA.
Source: Medicine (Baltimore), 1997 Jul, 76:4, 284-94
Abstract: Musculoskeletal infections constitute an unusual clinical manifestation in patients with human immunodeficiency virus (HIV) infection. Available information about patients' characteristics and their clinical course has been obtained mainly from case reports and small retrospective studies. Our retrospective study is the largest in the literature providing detailed information about the clinical and laboratory characteristics of HIV-infected patients with different musculoskeletal infections. We identified 30 patients with various infections of the musculoskeletal system during a 5-year period among a cohort of 3,000-4,000 HIV-infected patients, and we describe them along with all cases of musculoskeletal infections in patients with HIV reported in the literature since 1985. Septic arthritis was the most commonly reported infection of the musculoskeletal system. It usually affects young men with a median CD4 count of 241. The exact contribution of a previous history of intravenous drug abuse in the pathogenesis of septic arthritis is unclear from the present and previous studies. Staphylococcus aureus was the most commonly isolated agent (31.3%). Numerous atypical pathogens were also identified as causes of septic arthritis. Approximately 90% of patients recovered with appropriate antibiotic treatment. Osteomyelitis was a more serious infection which also affected young individuals but with lower CD4 counts (median, 41). Half the cases were due to atypical mycobacteria. The mortality rate in the previously reported cases and in our series was high (20%). Pyomyositis is an increasingly recognized infection of the striated muscles in HIV-infected patients. It affects almost exclusively males with advanced HIV infection (median CD4 count, 24). Most cases are due to Staphylococcus aureus (67%). Drainage of the involved muscle(s) accompanied by proper antibiotic treatment resulted in resolution of the infection in the majority of patients (90%). Although the incidence of musculoskeletal infections in patients with HIV from this and previous studies appears to be low (0.3%-3.5%), these infections add a significant morbidity and mortality in the affected individuals. Better understanding of their pathogenesis and clinical course would aid the proper diagnosis and management of these infections.
Language of Publication: English
Unique Identifier: 97425284

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MeSH Heading (Major): Arthralgia|CO/*MI; Arthritis, Infectious|CO/*MI; Bacterial Infections|*CO; Bursitis|CO/*MI; HIV Seropositivity|*CO; Osteomyelitis|CO/*MI; Polymyositis|CO/*MI
MeSH Heading: Adult; Female; Human; Male; Middle Age; Retrospective Studies; Syphilis|CO

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES; REVIEW, TUTORIAL
ISSN: 0025-7974
Country of Publication: UNITED STATES

Record 97 from database: MEDLINE
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Title: Effects of cyclosporin on joint damage in rheumatoid arthritis. The Italian Rheumatologists Study Group on Rheumatoid Arthritis.
Author: Ferraccioli GF; Bambara LM; Ferraris M; Perpignano G; Cattaneo R; Porzio F; Accardo S; Mattara L; Zoppini A; Benucci M; Ostuni PA; Pasero G
Address: Rheumatic Disease Unit, Universit of Udine, Italy.
Source: Clin Exp Rheumatol, 1997 May, 15 Suppl 17:, S83-9
Abstract: According to the most recent literature, few antirheumatic drugs can claim disease-controlling properties over the anatomical joint damage in rheumatoid arthritis (RA). A small number of studies have favored one or another of the available agents, in particular parenteral gold salts, sulphasalazine and methotrexate, but the evidence regarding their efficacy is not convincing when analysed using methodological criteria known to be important in evaluating radiologic evidence of joint damage. The radiologic results in long-standing RA patients have shown that CsA may be of benefit in reducing disease progression. Data from the second year of a clinical trial designed to compare the disease-controlling, anti-rheumatic properties of CsA with those of conventional disease-modifying anti-rheumatic drugs (DMARDs) in early RA support the hypothesis that CsA may be useful in delaying the appearance of new joint erosion.
Language of Publication: English
Unique Identifier: 97411116

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MeSH Heading (Major): Antirheumatic Agents|*TU; Arthritis, Rheumatoid|*DT/PP/RA; Cyclosporine|*TU; Joints|*DE/PA
MeSH Heading: Adult; Arthrography; Clinical Trials; Human; Male; Middle Age; Treatment Outcome

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
ISSN: 0392-856X
Country of Publication: ITALY

Record 98 from database: MEDLINE
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Title: The economic cost and social and psychological impact of musculoskeletal conditions. National Arthritis Data Work Groups [see comments]
Author: Yelin E; Callahan LF
Address: Arthritis Research Group, University of California, San Francisco 94109, USA.
Source: Arthritis Rheum, 1995 Oct, 38:10, 1351-62
Abstract: OBJECTIVE. To provide an indication of the economic, social, and psychological impact of musculoskeletal conditions in the United States. METHODS. Review of the literature combined with estimates of data concerning health care utilization and acute and chronic disability due to musculoskeletal conditions, from the 1990-1992 National Health Interview Survey. RESULTS. The cost of musculoskeletal conditions was $149.4 billion in 1992, of which 48% was due to direct medical care costs and the remainder was due to indirect costs resulting from wage losses. This amount translates to approximately 2.5% of the Gross National Product, a sharp rise since the prior studies, even if part of the increase is an artifact of improved accounting methods. Each year, persons with musculoskeletal conditions make 315 million physician visits, have more than 8 million hospital admissions, and experience approximately 1.5 billion days of restricted activity. Approximately 42% of persons with musculoskeletal conditions--more than 17 million in all--are limited in their activities. CONCLUSION. The economic and social costs of musculoskeletal conditions are substantial. These conditions are responsible for a sizable amount of health care use and disability, and they significantly affect the psychological status of the individuals with the conditions as well as their families.
Language of Publication: English
Unique Identifier: 96017433

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MeSH Heading (Major): Cost of Illness|*; Depression|*ET; Musculoskeletal Diseases|CO/*EC/*PX
MeSH Heading: Activities of Daily Living; Adolescence; Adult; Aged; Child; Female; Health Care Costs; Human; Middle Age; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW LITERATURE
ISSN: 0004-3591
Country of Publication: UNITED STATES

Record 99 from database: MEDLINE
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Title: Human immunodeficiency virus-associated atypical mycobacterial skeletal infections [published erratum appears in Semin Arthritis Rheum 1996 Aug;26(1):504]
Author: Hirsch R; Miller SM; Kazi S; Cate TR; Reveille JD
Address: Department of Medicine, University of Texas Health Science Center-Houston 77225, USA.
Source: Semin Arthritis Rheum, 1996 Apr, 25:5, 347-56
Abstract: The clinical and laboratory features of six human immunodeficiency virus (HIV)-positive patients with atypical mycobacterial skeletal infections, seen at a county outpatient HIV facility or university outpatient clinic, are reviewed and compared with other reported cases. Atypical mycobacterial skeletal infections are a manifestation of advanced HIV disease, with most cases having CD4 counts < 100/mm3 at the time these infections become clinically apparent. Multiple sites are frequently involved, and concomitant skin infection with the same organism is common, especially with Mycobacterium haemophilum. The incidence of atypical mycobacterial skeletal infection in HIV-infected individuals was significantly higher than in the general county hospital district patient population, whereas the frequency of Myobacterium tuberculosis skeletal infection did not differ significantly between the two populations. The clinician therefore should maintain a high index of suspicion for atypical mycobacteria in a patient presenting with skeletal infection in the setting of a markedly depressed CD4 count.
Language of Publication: English
Unique Identifier: 96272078

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MeSH Heading (Major): AIDS-Related Opportunistic Infections|*EP; HIV-1|*; Mycobacterium Infections|*VI; Mycobacterium, Atypical|*VI; Osteomyelitis|*MI/*VI
MeSH Heading: Adult; Arthritis, Infectious|MI/VI; Case Report; Human; Incidence; Male; Middle Age; Muscle, Skeletal|MI/VI; Support, U.S. Gov't, P.H.S.

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0049-0172
Country of Publication: UNITED STATES

Record 100 from database: MEDLINE
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Title: The coexistence of systemic sclerosis and rheumatoid arthritis in five patients. Clinical and immunogenetic features suggest a distinct entity.
Author: Horiki T; Moriuchi J; Takaya M; Uchiyama M; Hoshina Y; Inada K; Inoko H; Tsuji K; Ichikawa Y
Address: Tokai University School of Medicine, Kanagawa, Japan.
Source: Arthritis Rheum, 1996 Jan, 39:1, 152-6
Abstract: To elucidate the clinical characteristics and pathogenesis of scleroderma-rheumatoid arthritis (SSc-RA) overlap syndrome, we analyzed the clinical features of 5 patients with SSc-RA overlap. Their HLA phenotypes and genotypes were also determined. Generalized skin sclerosis, severe seropositive polyarthritis, pulmonary fibrosis, anti-topoisomerase I antibodies, and HLA-DR4,53;DQA1*0301;DBQ1*04 haplotype were observed in all of the patients. Similar clinical features were recognized in most of the 10 cases reported previously. Our case studies indicate that SSc-RA overlap may be a distinct entity.
Language of Publication: English
Unique Identifier: 96133274

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MeSH Heading (Major): Arthritis, Rheumatoid|BL/*CO/IM; Scleroderma, Systemic|BL/*CO/IM
MeSH Heading: Aged; Case Report; Female; Human; HLA-DQ Antigens|BL; HLA-DR Antigens|BL; Male; Middle Age; Phenotype; Support, Non-U.S. Gov't

Publication Type: JOURNAL ARTICLE; REVIEW; REVIEW OF REPORTED CASES
ISSN: 0004-3591
Country of Publication: UNITED STATES

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